The immunogenetics of measles immunity
This project focuses on genes that influence and determine the human immune response to the measles vaccine. This knowledge allows for a better understanding of how measles immunity develops after vaccination and why a range of immune responses occurs.
Innate immune function in older adults
This project, funded by the Robert and Arlene Kogod Center on Aging at Mayo Clinic, focuses on the interaction between influenza vaccination and inflammasomes and the impact of senescence — the condition or process of deterioration with age — on this interaction, along with the subsequent adaptive immune response to the influenza virus.
Translating the discovery of immunogenic measles peptides into a candidate vaccine
The Vaccine Research Group has identified 13 naturally processed HLA-DRB1*03-restricted measles peptides. The current live-virus measles vaccine is highly effective and widely used; however, outbreaks among vaccinated individuals continue to occur. Difficulties encountered with the current vaccine include preexisting maternal antibodies that suppress response to the vaccine, cold chain requirements for vaccine viability, contraindicated use in immunocompromised individuals and the requirement for trained health care providers to administer the vaccine. The group's ability to identify critical measles epitopes is a significant step in developing a safe and effective peptide-based measles vaccine that circumvents these issues related to vaccine failure.
See Vaccine Research Group publications related to measles and peptides.
See all publications by Mayo Clinic authors related to measles.
Learn about diagnosis and treatment of measles.