The Tendon and Soft Tissue Biology Laboratory of Peter C. Amadio, M.D., at Mayo Clinic focuses its research on injuries to tendons and soft tissues.

Flexor tendon injury and repair poses a surgical challenge because of the high complication rate, including adhesion formation, gapping and rupture, which typically require a second surgery to restore finger function.

Research goals and topics

The research goals of Dr. Amadio's Tendon and Soft Tissue Biology Lab focus on several important aspects related to improving the outcomes of flexor tendon repair.

These include:

  • Lubricant effect
  • Optimal postoperative rehabilitation
  • Appropriate surgical repair and reconstruction techniques
  • Role of growth factor on tendon healing and adhesion formation

Current research topics within the Tendon and Soft Tissue Biology Lab relate to a wide range of disciplines and technologies, such as orthopedics, biomechanics, biochemistry, dynamic ultrasound, and molecular and cell biology.

About Dr. Amadio

Dr. Amadio is the Lloyd A. and Barbara A. Amundson Professor of Orthopedics, with joint appointments in the Mayo Clinic Division of Health Care Policy & Research and the Department of Physiology and Biomedical Engineering.

Dr. Amadio is an active member of the Division of Hand Surgery in the Department of Orthopedic Surgery, and his clinical interests include congenital hand diseases, upper extremity tumors and distal upper extremity tendon injuries.

The goal of Dr. Amadio's lab is to improve the results of tendon repair by applying tissue engineering approaches to two interrelated issues:

  • The effect of loading on wound healing and soft tissue material properties (Wolff's law of soft tissue)
  • The effect of tendon repair and lubrication on tendon gliding

Dr. Amadio's research interests include:

  • Outcomes research
  • Tendon healing
  • Effect of mechanical forces on soft tissue remodeling (Wolff's law of soft tissue)