News

Read about events and accomplishments in Dr. Grinberg's lab as well as Alzheimer's and neurodegenerative disease research updates from the Mayo Clinic News Network.

2026

June

  • Department of Neuroscience retreat and presentations. Multiple lab members presented at the retreat.
    • Cice Chen presented a poster titled "Molecular and Spatial Dissection of Orexinergic Neuron Subpopulation Vulnerability in Alzheimer's Disease."
    • Jonathan Chen presented a poster titled "High-Resolution Computational Histology Resolves Ongoing Amyloid-Beta Accumulation Beyond the Neuroimaging Plateau."
    • Ana Moreno Arnas presented a poster titled "Tau Mediated Suprachiasmatic Nucleus Vulnerability in Amnestic Alzheimer's Disease: Neuropathological Basis for Circadian Dysfunction."
    • Marina M. Reinhardt presented a poster titled "Development and Standardization of a Targeted Minimally Invasive Tissue Sampling (MITS) Protocol for Post-Mortem Brain Biobanking."
    • Felipe L. Pereira, Ph.D., gave a talk titled "Single-Nucleus Transcriptomics Identifies Common Selective Neuronal Vulnerability but Divergent Molecular Signatures Across Alzheimer's Disease Phenotypes."
    • Abhijit Satpati, Ph.D., presented a poster titled "Against the Tide: Pro-Survival and Compensatory Anti-Inflammatory Responses in Histaminergic Neurons Amid Tau Accumulation in Alzheimer's Disease.
    • Gowoon Son, Ph.D., presented a poster titled "Spatially Resolved Autophagic Heterogeneity Shapes Tau Selective Vulnerability in Human Master Circadian Clock."
    • Lucile H. Zhu presented a poster titled "A Convolutional Neural Network Classifier for Macroscopic Whole Slide Images."
  • Grand Rounds presentation. Dr. Grinberg presented at Mayo Clinic Florida Pulmonary Grand Rounds. The title of her presentation was "Neuropathological Basis of Sleep Dysfunction in Alzheimer's Disease and Progressive Supranuclear Palsy: Clinical, Diagnostic, and Therapeutic Implications."
  • New lab member. Jackie Barua, M.B.B.S., Ph.D., joined the Grinberg Lab.
  • Department of Neuroscience talk. Dr. Grinberg's lab hosted a presentation by Dr. Pereira titled "Single-Nucleus Transcriptomics Identifies Common Selective Neuronal Vulnerability but Divergent Molecular Signatures Across Alzheimer's Disease Phenotypes."
  • American Association of Neuropathologists presentation. Dr. Son presented a poster at the American Association of Neuropathologists' 102nd Annual Meeting on June 4 to 7, 2026. The title of her presentation was "Spatially Resolved Transcriptomic Heterogeneity Shapes Tau Selective Vulnerability in Human Master Circadian Clock in Alzheimer's Disease."

May

  • Panel discussion on brain health. Dr. Grinberg participated in the "Leadership in Action: Global Brain Health Satellite Sessions" panel. The discussion was part of the 10-year anniversary of the Global Brain Health Institute and the Atlantic Fellows for Equity in Brain Health program.
  • Keynote address at allied health symposium. Dr. Grinberg was the keynote speaker at Mayo Clinic's Research Allied Health Association (RAHA) Symposium. The annual RAHA Symposium, now in its sixth year, provides a venue for allied health staff to showcase their accomplishments, network with colleagues, and be recognized and celebrated for their contributions to research at Mayo Clinic.
  • RAHA presentations. Two members of the Grinberg Lab presented at the Sixth Annual Research Allied Health Symposium. Dr. Satpati spoke on "Resilience of Histaminergic Neurons to Tau Toxicity: A Therapeutic Target to Mitigate Sleep-Wake Dysfunction in Alzheimer's Disease." Jonathan Chen's presentation was titled "High-Resolution Computational Histology Resolves Ongoing Amyloid-Beta Accumulation Beyond the Neuroimaging Plateau."

April

  • Plenary talk at ISFTD EMCR. Dr. Grinberg gave a plenary talk at the International Society for Frontotemporal Dementias Early and Mid-Career Researcher (ISFTD EMCR) Symposium. Her topic was "Navigating an Evolving FTD Landscape: Scientific Frontiers, Collaboration and Career Choices for Early Investigators."
  • Keynote address at Synuclein event. Dr. Grinberg was the keynote speaker at the 2026 Synuclein Biomarker and Pathology Summit.
  • Postdoctoral fellowship. Dr. Son was awarded a postdoctoral fellowship from BrightFocus Foundation. The foundation supports innovative and diverse Alzheimer's disease research aimed at advancing understanding, prevention and treatment.
  • Alzheimer's Disease Research Day travel award and lightning talk. Dr. Satpati received a travel accommodation award to attend Alzheimer's Disease Research Day 2026. Dr. Satpati presented a lightning round talk on April 15, 2026. The title of his presentation was, "Focus on Orexinergic Neurons: Omics Study Reveals Neuroinflammation in the Lateral Hypothalamic Area as the Key Factor Driving the Initial Vulnerability in Alzheimer's Disease." The event was led by the Wisconsin Alzheimer's Disease Research Center Research Education Component and took place April 14 to16, 2026.
  • New lab member. Ahnaf A. Rahman joined the Grinberg lab.

March

  • AP/PD 2026 think tank and plenary session. Dr. Grinberg participated at the 2026 International Conference on Alzheimer's and Parkinson's Diseases and Related Disorders, known as AP/PD 2026. By invitation, Dr. Grinberg took part in the preconference think tank in Copenhagen, Denmark. She also led a plenary session at the conference titled "Understanding Neurodegenerative Diseases Today: Lessons from Clinicopathological Correlations and the Ongoing Role of Neuropathology in the Biomarker Age."
  • Section and debate leadership at CONy 2026. Dr. Grinberg served as the neuropathology section lead at the 20th World Congress on Controversies in Neurology (CONy) in Krakow, Poland. She also led the CONy debate "Should We Treat Preclinical Alzheimer's Based On Biomarker Evidence Only?"
  • Laboratory Medicine and Pathology Grand Rounds. Dr. Grinberg spoke at the Laboratory Medicine and Pathology Grand Rounds at Mayo Clinic in Florida. Her presentation was titled "Understanding Neurodegenerative Diseases Today: Lessons from Clinicopathological Correlations and the Ongoing Role of Neuropathology in the Biomarker Age."
  • International Conference on Alzheimer's and Parkinson's Diseases plenary session. Dr. Grinberg's presentation was titled "Understanding Neurodegenerative Diseases Today: Lessons from Clinicopathological Correlations and the Ongoing Role of Neuropathology in the Biomarker Age."
  • Alzheimer's & Dementia article published. Dr. Son and Dr. Satpati jointly published an article in Alzheimer's & Dementia, the journal of the Alzheimer's Association. The article is titled "Sex Differences in Neuromodulatory Subcortical Systems and Their Implications for Alzheimer's Disease."
  • Academic rank awarded. Dr. Pereira was appointed assistant professor of neuroscience at Mayo Clinic School of Medicine and Science.
  • Presenters and posters at the Tau Global Conference. Several lab members were selected for awards and presentations at the Tau Global Conference 2026 in Washington, D.C.
    • Dr. Son won a fellowship to attend and give a talk. Her presentation was titled "Spatially Resolved Autophagic Heterogeneity Shapes Tau Selective Vulnerability in Human Master Circadian Clock."
    • Liara Rizzi, Ph.D., M.S., won a fellowship to attend. Her poster presentation was titled "Early Accumulation of Truncated Tau With Incomplete, Stage-Dependent Overlap With Phosphorylated Tau in Alzheimer's Disease."
    • Dr. Satpati was selected for an in-person poster presentation. It was titled "Against the Tide: Pro-Survival and Compensatory Anti-Inflammatory Responses in Histaminergic Neurons Amid Tau Accumulation in Alzheimer's Disease."
  • Alzheimer's & Dementia article published. Jonathan Chen is a coauthor on a paper that was published in Alzheimer's & Dementia. The paper is titled "Correlation Between In Vivo 18F-Flortaucipir Positron Emission Tomography and Whole Brain Postmortem Histological Tau Signals in Alzheimer's Disease."
  • AAIC 2026 invitations. Multiple lab members received invitations to present at the Alzheimer's Association International Conference (AAIC) 2026 taking place July 12 to 15, 2026, in London, England.
    • Dr. Pereira will give a talk during a featured research presentation. The session title is "Vulnerability in AD and Tauopathies," and the title of his talk is "Single-Nuclei Transcriptomics Identifies Common Neuronal Cell Vulnerability in Alzheimer's Disease Variants."
    • Ana Moreno Arnas' poster presentation is titled "Tau Mediated Suprachiasmatic Nucleus Vulnerability in Amnestic Alzheimer's Disease: Neuropathological Basis for Circadian Dysfunction."
    • Lucile H. Zhu's poster presentation is titled "A Convolutional Neural Network Classifier for Low-Resolution Whole Slide Images."
    • Jonathan Chen's poster presentation is titled "High-Resolution Computational Histology Resolves Ongoing Amyloid-Beta Accumulation Beyond the Neuroimaging Plateau."
    • Dr. Satpati's poster presentation is titled "Metabolic Versus Inflammatory Profiles Distinguish Amnestic and Atypical Alzheimer's Disease: Insights From the Orexinergic System."

February

  • Journal of Neuropathology and Experimental Neurology article published. Dr. Grinberg's article titled "Clinicopathological Study of Chronic Traumatic Encephalopathy Pathology in a Population-Based Cohort" was published in the Journal of Neuropathology and Experimental Neurology.

January

  • In Acta Neuropathologica paper accepted. A paper by Jonathan Chen and Dr. Pereira titled "Disentangling On and Off-Target Binding in Flortaucipir PET: A Voxel-to-Voxel P-Tau, Ferric Iron, and MAO-B Histology-to-Flortaucipir PET Comparison" was accepted for publication in In Acta Neuropathologica.
  • Annals of Neurology paper accepted. Jonathan Chen is the co-author of a paper accepted into Annals of Neurology. The title is "Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths."

2025

December

  • Cure Alzheimer's grant. Dr. Grinberg was awarded a two-year grant from the Cure Alzheimer's Fund for a project titled "Linking Sleep Dysfunction to Tau-Related Degeneration Across Alzheimer's Disease Variants."
  • Article published in Alzheimer's & Dementia. Jonathan Chen, Dr. Periera, Lucile Zhu and Dr. Grinberg published "Unveiling the Distinct Roles of P-Tau, Iron and MAOB in Neurobiological Basis of F18‐Flortaucipir Signal With Voxel‐to‐Voxel Histology to PET Analysis in Different Tauopathies" in the journal Alzheimer's & Dementia.
  • TREAT-AD talk. Dr. Pereira gave a talk at a Target Enablement to Accelerate Therapy Development for Alzheimer's Disease (TREAT-AD) meeting.
  • Dr. Grinberg named as a 2025 influential researcher. Dr. Grinberg was included in Clarivate's list of highly cited researchers of 2025.
  • JAMA Neurology paper accepted. Dr. Grinberg's paper titled "Sex Differences in Amyloid and Cognitive Outcomes" was accepted for publication in JAMA Neurology.
  • Dr. Son accepted to scholar program. Dr. Son was selected for the American Association of Neuropathologists' Neurodegenerative Disease Scholars Program.

October

  • Winning poster presentation. Dr. Son won first place for her poster presentation at the 2025 James C. and Sarah K. Kennedy Dean of Research Retreat hosted by Mayo Clinic in Florida.
  • ADRC meeting discussion and roundtable leadership. Dr. Grinberg led a Neuropathology Core meeting session and subsequent roundtable discussion at the fall 2025 meeting of the National Alzheimer's Coordinating Center's Alzheimer's Disease Research Centers program.

August

  • Society for Neuroscience award. Dr. Son was awarded the Society for Neuroscience's Trainee Professional Development award, which recognizes scientific merit and excellence in research. Recipients received a travel stipend to offset the costs of attending Neuroscience 2025 as well as a complimentary registration. All in-person recipients presented their abstracts during a special poster session and attended two professional development workshops during the meeting.

2024

July

  • Grinberg Lab presentation at AAIC24. Published researchers from the Grinberg Lab presented at the 2024 Alzheimer's Association International Conference in Philadelphia, Pennsylvania. They shared the lab's recent findings, which advance knowledge about Alzheimer's disease and dementia.