Research Themes

The Human and Integrative Physiology and Clinical Pharmacology Laboratory has numerous ongoing research themes.

In general, Dr. Joyner and his research team focus on how various forms of physical stress and mental stress influence the cardiovascular and respiratory systems. These studies are supported by our grants from the National Institutes of Health and the Department of Defense.

Highlights of some of our current research projects include:

  • Studies on factors that can influence oxygen binding to hemoglobin and how any changes in the oxygen hemoglobin dissociation curve influence responses to exercise, hypoxia and blood loss
  • How exercise influences the effects of bronchodilating drugs in patients with cystic fibrosis
  • How acute administration of estrogen influences endothelial function in middle-aged men
  • How brain oxygen levels influence the physiological response to exercise in muscles that are ischemic
  • How body position influences muscle oxygenation during cycling
  • The use of machine learning to help predict catastrophic blood loss in people who are undergoing both simulated and real experimental blood loss