Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
Research in the laboratory of Wuqiang Zhu, M.D., Ph.D., focuses on understanding the pathophysiology of heart failure and developing therapeutic approaches for cardiac regeneration and repair. The proliferative capacity of cardiomyocytes in the adult mammalian heart is too low to promote structural and functional recovery after injuries. Disorders of ventricular function and structure after ischemic injury reduce cardiac output and can impair diastolic relaxation of the heart, leading to heart failure. Current therapeutic regimens do not address the root cause of heart failure due to ischemic injury, such as the loss of cardiomyocytes and their replacement by a non-contractile fibrous scar.
Heart failure is a costly and deadly condition affecting over 5 million Americans. The research in Dr. Zhu laboratory uses in vitro and in vivo models, as well as human biopsy samples, to understand the pathogenesis of heart failure and to develop novel therapeutics to enhance cardiac regeneration and cardioprotection in patients with heart failure.
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