Rochester, Minnesota


Zhao.Yulian@mayo.edu Clinical Profile


Yulian Zhao, M.D., Ph.D., studies methodologies for reproductive tissue banking, especially fertility preservation for young cancer patients. Dr. Zhao is also researching quality indicators and success factors during in vitro fertilization (IVF) treatment cycles, aiming to improve pregnancy outcome.

Cure rates and long-term survival of childhood cancer has increased significantly and one medical late effect of cancer treatment is infertility or compromised fertility. Dr. Zhao's research focuses on technologies to preserve fertility by preserving reproductive tissues (testicular and ovarian tissues) and regeneration of germ cells from gonadal tissues to be used in assisted reproduction.

Focus areas

  • Optimizing methodologies for ovarian tissue cryopreservation for fertility preservation. This study examines the efficacy of slow cooling and vitrification processes aimed at maximizing the survival and functionality of ovarian tissue by the time of tissue thawing and utilization.
  • Dissociation of spermatogonia stem cells from testicular tissues. The goal of this effort is to generate germ cells from immature testicular tissue with potential to restore fertility for prepubescent male patients at risk of compromised fertility.
  • Examining and identifying success factors and indicators in IVF treatment cycles. Through machine learning, this research is to utilize data generated nationally and institutionally to assess the most important and relevant factors that affect IVF success.

Significance to patient care

Dr. Zhao's research aims to optimize and enhance the opportunities to help patient preserving fertility before fertility-threatening treatment, and to improve IVF outcomes through progression of assisted reproductive technologies.


Primary Appointment

  1. Consultant, Department of Obstetrics & Gynecology

Joint Appointment

  1. Consultant, Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology

Academic Rank

  1. Professor of Obstetrics and Gynecology


  1. MBA Johns Hopkins University Carey Business School
  2. Certificate - Strategic Planning in Medical Organizations Johns Hopkins University School of Medicine
  3. Certificate - Marketing Management in Medical Organizations Johns Hopkins University School of Medicine
  4. Certificate - Medical Informatics Johns Hopkins University School of Medicine
  5. Certificate - Human Resource Management in Health Care Organizations Johns Hopkins University School of Medicine
  6. Other - The Basics of Financial Administration: An Overview of the Business Side of Hopkins Management and Staff Development Program Johns Hopkins University School of Medicine
  7. Post Doctoral Researcher - Extracellular Matrix Proteins in the Ovary University of Nottingham
  8. Post Doctoral Researcher - Uterine gene expression and molecular biology Babraham Institute
  9. Ph.D. - Reproductive Physiology Harbin Medical University
  10. Masters - Reproductive Physiology Harbin Medical University
  11. MD - Medicine Harbin Medical University

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