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The research of Na Zhao, M.D., Ph.D., is focused on understanding the physiological and pathological functions of apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2) in aging and aging-related diseases and disorders. Specifically, Dr. Zhao's Neurobiology of Alzheimer Related Dementias Laboratory focuses on dissecting the molecular and cellular mechanisms underpinning the pathogenesis of Alzheimer's Disease (AD) and related dementias such as Lewy body dementia (LBD) with a particular highlight on the roles of APOE and microglial function through TREM2.
Using techniques spanning biochemistry, cell biology, animal modeling and induced pluripotent stem cell (iPSC) culturing modeling, Dr. Zhao's lab aims to conduct translational research to find targeted therapeutic strategies for these devastating neurodegenerative diseases.
The ultimate goal of Dr. Zhao's work is to gain a deep perspective into disease mechanisms in AD and related disorders to discover targeted therapeutics to treat them.
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