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The research goal of Jing Zhao, M.D., Ph.D., is to study the pathogenic pathways of age-related neurodegenerative diseases. Specifically, Dr. Zhao focuses on the contributions of apolipoprotein E (APOE) and APOE receptors in Alzheimer's disease. Her research aims to determine how APOE isoforms and related receptors influence the pathological progression of Alzheimer's disease using biochemical and molecular approaches through different disease models. Dr. Zhao is using patient-derived induced pluripotent stem cells as a novel model to investigate the disease pathogenesis and explore potential for stem cell therapy to treat Alzheimer's disease.
In today's aging society, an increasing number of patients have neurodegenerative diseases, which impose social problems and worldwide economic loss. Dr. Zhao's research provides better understanding of the molecular mechanisms in the disease pathogenesis and will yeild novel targets to develop effective therapeutic interventions for these diseases.
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