Rochester, Minnesota


Weroha.Saravut@mayo.edu Clinical Profile


Although poly (ADP-ribose) polymerase (PARP) inhibitors have been a great addition to the therapeutic options available for patients with ovarian cancer, additional therapies and therapeutic combinations are needed. Saravut (John) J. Weroha, M.D., Ph.D., hopes to use his translational research to develop those therapies for ovarian and other gynecological cancers.

Focus areas

  • Developing new therapeutic combinations with PARP inhibitors for ovarian cancer
  • Understanding mechanisms of resistance to PARP inhibitors in order to develop strategies to overcome resistance
  • Using patients' own tumors to predict responses to therapy in the clinic and advise on treatment
  • Lead and support clinical trials devoted to patients with gynecological malignancies
  • Expand the world's largest collection of patient-derived xenografts (avatars) by continuing to develop ovarian cancer models and adding models for endometrial and rare gynecological cancers

Significance to patient care

As a medical oncologist treating recurrent and new gynecological cancers, Dr. Weroha sees patients who are asking questions, looking for cures and searching for hope. Through his research, he turns to science to find the answers, develop the cures and create hope for these patients. Dr. Weroha's research goal is to contribute to the knowledge that will improve current therapies and create new ones for patients with ovarian cancer and other gynecological malignancies.


Primary Appointment

  1. Division of Medical Oncology, Department of Oncology

Academic Rank

  1. Assistant Professor of Pharmacology
  2. Assistant Professor of Medicine
  3. Associate Professor of Oncology


  1. Fellow Hematology/Oncology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Resident Clinician Investigator, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Internship/Residency - Internal Medicine, Clinical Investigator Program Internal Medicine, Mayo School of Graduate Medical Education
  4. MD University of Kansas School of Medicine
  5. PhD - Pharmacology, Toxicology and Therapeutics University of Kansas School of Medicine
  6. BS - Cellular Biology, with Honors and Distinction University of Kansas

Clinical Studies

Learn about clinical trials that address specific scientific questions about human health and disease.

See my studies.

Explore all research studies at Mayo Clinic.


See the peer-reviewed findings I have published as a result of my research.

Review publications.

Mayo Clinic Footer