Most diseases can be attributed at least in part to genetic mutations or epigenetic modifications. Current high-throughput sequencing approaches could produce massive data from clinical samples in a cost-effective manner to characterize patients' genomic and epigenomic landscapes. These data are valuable resources for researchers to identify disease-causing variants and facilitate personalized medicine.
The research of Liguo Wang, Ph.D., concentrates on the major theme of developing computational tools and methods to transform these immense data into biological knowledge and provide cognitive supports for data-informed clinical decision-making.
- Cancer biomarker discovery. Somatic mutation, copy number variation, epigenetic alteration and aberrant RNA splicing are common in human cancers. Dr. Wang's research focuses on identifying new and recurrent cancer biomarkers that are associated with tumor presence (diagnostic), progression and metastasis (prognostic), and drug-resistance (predictive).
- High-throughput sequencing data analysis, mining and integration. The amount of genomic data is growing exponentially and is spread over numerous heterogeneous data repositories. Dr. Wang's research focuses on developing bioinformatics solutions to analyze, integrate and interpret different types of molecular data including, whole-genome sequencing, whole-exome sequencing, transcriptome sequencing, bisulfite sequencing, ChIP sequencing and other types of epigenomic data.
- Prostate cancer development and progression. The androgen receptor (AR) plays critical roles in prostate cancer development, progression and metastasis. Dr. Wang's research focuses on using genome-wide approaches to study how the AR interacts with cis-regulatory DNA elements, trans-regulatory protein factors as well as the epigenetic environments during prostate cancer development and progression.
Significance to patient care
Big data promises precise medicine. Data-informed clinical decision-making demands storing, retrieving, analyzing and integrating a large amount of molecular and clinical data.
- Associate editor, BMC Bioinformatics, 2014-present