Rochester, Minnesota


Tweet.Marysia@mayo.edu Clinical Profile


The research interests of Marysia S. Tweet include cardiovascular disease in women and acute coronary syndromes, particularly those caused by spontaneous coronary artery dissection (SCAD). Dr. Tweet is currently involved in a multidisciplinary research program to study SCAD, including investigation of the natural history of the disease, management strategies, genetic predispositions and comorbid conditions such as fibromuscular dysplasia. She is also interested in the cardiovascular manifestations of pregnancy, CT imaging and MRI for evaluation of coronary artery disease, cardiovascular stress testing and the use of social media to accelerate research.

Focus areas

  • Spontaneous coronary artery dissection (SCAD). Dr. Tweet is working to increase understanding of the origins of SCAD, patterns of genetic predisposition to SCAD and optimal management strategies for improving outcomes.
  • Risks of pregnancy for cardiovascular patients. Specific areas of focus include investigations of pregnancy risk for SCAD patients and effects of hypertension during pregnancy.
  • Technologies for diagnosis of cardiovascular disease. Dr. Tweet is particularly interested in cardiovascular stress testing as well as CT imaging and MRI of coronary arteries.
  • Social media to propel research. Mayo Clinic's SCAD program is the result of patient activism and initiation in online communities. Based on this experience, Dr. Tweet is interested in researching and developing strategies to propel research via social media.

Significance to patient care

Dr. Tweet's overall goal is to improve the understanding and care of young patients presenting with acute coronary syndromes, especially SCAD, a condition about which little is known regarding pathophysiology, optimal management strategies and pregnancy decision-making. She aims to further understand the utility and meaning of stress testing in young people.

Professional highlights

  • Angela and Anne V. Marinelli endowed fellowship, Mayo School of Graduate Medical Education, 2014
  • Young Fibromuscular Dysplasia Investigator Travel Award, International Fibromuscular Dysplasia Research Symposium, 2014
  • Second place, Controversies in Cardiovascular Disease Fellows in Training Poster Competition, American College of Cardiology, 2011 and 2013
  • Women in Cardiology Trainee Award for Excellence, American Heart Association, 2012
  • Leonard Tow Humanism in Medicine Award, The Arnold P. Gold Foundation, 2008


Primary Appointment

  1. Consultant, Division of Ischemic Heart Disease and Critical Care, Department of Cardiovascular Medicine

Joint Appointment

  1. Consultant, Division of Cardiovascular Ultrasound, Department of Cardiovascular Medicine

Academic Rank

  1. Associate Professor of Medicine


  1. BASIC SCIENCE MASTERS Clinical and Translational Science, Programs, Mayo Graduate School, Mayo Clinic College of Medicine
  2. Fellow - Cardiovascular Diseases Mayo Graduate School of Medicine, Mayo Clinic College of Medicine, Department of Education Administration
  3. Resident - Internal Medicine Mayo Graduate School of Medicine, Mayo Clinic College of Medicine, Department of Education Administration
  4. MD University of Minnesota Medical School
  5. Bachelor - Bachelor of Biomedical Engineering University of Minnesota Institute of Technology

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