Rochester, Minnesota


Truty.Mark@mayo.edu Clinical Profile


Mark J. Truty, M.D., performs clinical and translational research in pancreatic, hepatobiliary and gastrointestinal cancers. His clinical research is in the multidisciplinary surgical treatment of advanced gastrointestinal cancers, with a focus on novel preoperative therapies. He also serves as an institutional principal investigator on clinical trials.

Dr. Truty's translational and basic science work focuses on development of personalized animal models of individual patient tumors removed at surgery or at biopsy, with the goal of identifying effective screening and therapeutic biomarkers, assessing preclinical chemotherapeutic drug efficacy, and modeling of ideal treatment sequencing.

In addition, Dr. Truty is evaluating diagnostic and treatment strategies to improve perioperative outcomes of gastrointestinal surgical patients in an effort to minimize complications after surgery. Specifically, he is looking at inhibition of endogenous pancreaticoenteric catalytic enzymes that he has found are linked to a variety of disorders.

The focus of Dr. Truty's clinical practice is on patients with complex or advanced pancreatic, hepatobiliary and gastrointestinal malignancies.

Focus areas

  • Pancreatic cancers
  • Liver cancers — primary and metastatic
  • Bile duct and gallbladder cancers
  • Carcinoid tumors
  • Gastric cancers
  • Intestinal tumors
  • Sarcomas

Significance to patient care

Dr. Truty's research may assist in earlier diagnosis as well as in the development of novel personalized systemic treatments and ideal treatment sequencing for various types of cancers. In addition, his work may potentially prevent and minimize postoperative complications in patients undergoing complex gastrointestinal cancer surgery in order to improve overall survival and quality of life.


Primary Appointment

  1. Consultant, Division of Subspecialty General Surgery, Department of Surgery

Academic Rank

  1. Associate Professor of Surgery


  1. Certificate - Tableau Data Visualizations Center for Advanced Computing, Cornell University
  2. Certificate - The Business of Healthcare Specialization Certificate Wharton School of Business, University of Pennsylvania
  3. Chief Fellow University of Texas M.D. Anderson Cancer Center
  4. Postdoctoral Research Fellowship - Patient-Based Biological Research Program University of Texas M.D. Anderson Cancer Center
  5. Fellow - Advanced Surgical Oncology University of Texas M.D. Anderson Cancer Center
  6. Chief Resident - General Surgery Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  7. Senior Resident - General Surgery Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  8. Postdoctoral Research Fellowship Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Department of Internal Medicine
  9. Internship and Junior Residency - General Surgery Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  10. Master of Science - Pathology Chicago Medical School
  11. Doctorate of Medicine - Medicine Chicago Medical School
  12. Master of Science - Physiology Chicago Medical School
  13. Bachelor - Biological Sciences University of Chicago

Clinical Studies

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