Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
The research lab led by Rory L. Smoot, M.D., is interested in understanding the mechanisms of altered liver regeneration, as well as those underlying the progression and development of cholangiocarcinoma. Dr. Smoot's team uses several techniques and models to understand these processes including next-generation sequencing and advanced proteomic analysis.
Dr. Smoot's research has two main potentially translational benefits. First, understanding the regulatory mechanisms driving tumor development, progression and response to therapy in cholangiocarcinoma can help identify new single-agent and combinatorial therapeutic approaches. This is especially important because cholangiocarcinoma is a notoriously difficult cancer to treat and currently has limited survival. Second, by using small molecules to target and accelerate liver regeneration, Dr. Smoot hopes to provide a therapeutic approach for patients who have poor liver regeneration and function after liver surgery.
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