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The research interests of Joshua R. Smith, Ph.D., are centered on identifying therapeutic targets within the nervous and cardiovascular systems that can improve responses to physical stress (such as exercise) in healthy adults and patients with cardiovascular disease. Specifically, he is interested in how the respiratory muscles negatively influence exercise responses in patients with heart failure as well as what interventions might improve these impaired responses.
Dr. Smith is also interested in how sex-specific mechanisms such as menopause impact the cardiovascular response to physical stress in health and cardiovascular disease. Lastly, Dr. Smith has a special interest in investigating sex differences in cardiac rehabilitation outcomes.
The goal of Dr. Smith's research is to improve symptomology, exercise tolerance and quality of life for patients with heart failure by contributing to a better understanding of respiratory muscle dysfunction and associated cardiovascular consequences. He investigates novel interventions that aim to improve respiratory muscle function as well as identify the mechanistic underpinnings of worsened neural and cardiovascular control in patients with heart failure. Dr. Smith also seeks to elucidate how sex- and menopause-specific mechanisms both impact cardiovascular responses to physical stress and mediate improvements following cardiac rehabilitation.
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