Shane A. Shapiro, M.D., is dedicated to advancing the science of orthopedics and regenerative medicine through research. He is the principal investigator of the world's first randomized controlled study of bone marrow-derived stem cells to treat knee arthritis — early results of this clinical trial were published in the American Journal of Sports Medicine.
Early in his career, Dr. Shapiro worked at the Collins laboratory at the National Institutes of Health (NIH) to map every gene in the human body for the Human Genome Project. Currently, his research focus is to study novel regenerative techniques for chronic nonhealing bone, joint, muscle, tendon and skin maladies that are not candidates for conventional surgical management. Examples include stem cell therapy for arthritis, platelet-rich plasma injections for chronic tendinopathies, and the use of living, cell-based biological applications for chronic nonhealing wounds.
As medical director for the Regenerative Medicine Therapeutics Program at Mayo Clinic's campus in Florida, Dr. Shapiro broadens the scope of his research to forge collaborations between medical specialties. Such partnerships have resulted in the following projects:
- Human cell therapy to treat male- and female-pattern baldness
- Bone marrow stem cells for low back pain caused by intervertebral disc disease and spine degeneration
- Bone marrow stem cells to treat erectile dysfunction caused by radical prostatectomy
- Fat-derived stem cells to treat aerodigestive fistulas
- Collaboration with Alfredo Quinones-Hinojosa, M.D., in the Brain Tumor Stem Cell Research Lab seeking novel therapeutic approaches to use fat-derived stem cells to fight brain tumors
- Collaboration with Tushar C. Patel, M.B., Ch.B., and Joy Wolfram, M.D., to study the biological role of extracellular vesicles and their use as novel therapeutic agents to treat osteoarthritis
Significance to patient care
Regenerative medicine therapies hold the promise to repair, replace or restore tissues and organs injured by trauma and disease. The discovery and translation of these strategies and techniques share a common thread in their ability to mobilize the body's ability to heal and repair tissue where previously it had failed to do so. They form a foundation for the future of cell-based therapies for orthopedic diseases.
- Diplomat, American Board of Regenerative Medicine, 2017
- Registered in musculoskeletal ultrasound, American Registry for Diagnostic Medical Sonographers, 2013
- Certificate of Added Qualification in Sports Medicine (CAQSM) 2005
- Intramural Research Training Award from The National Institutes of Health 1996-1997