Rochester, Minnesota


Saris.Daniel@mayo.edu Clinical Profile


The research efforts of Daniel B.F. Saris, M.D., Ph.D., focus on optimizing the regenerative biological reconstruction of joints and the musculoskeletal system, improving treatment for and understanding of knee injuries, and developing advanced imaging and early intervention strategies.

Dr. Saris specializes in knee surgery from the simplest meniscus repair to complex knee problems including partial and total knee arthroplasty, osteotomy, joint distraction, and complex ligament reconstructions. His specific expertise is in regenerative medicine and cartilage repair with cell technology, and he is recognized internationally for his advanced strategies for complex knee reconstruction using tissues and biomaterials. He helped establish ChondroCelect in the EU ATMP registry and MACI in EMA and Food and Drug Administration registration. Dr. Saris is the inventor of IMPACT one-stage cell therapy. He has an active interest in patient information modernization, and his goal is to provide personalized, reliable, cost-efficient care.

Focus areas

  • Anterior cruciate ligament (ACL) injuries and reconstruction
  • Arthroscopy
  • Cartilage injuries
  • Joint replacement
  • Knee arthritis
  • Knee ligament injuries
  • Knee replacement
  • Meniscus tears and repairs
  • Patellar and quadriceps tendinitis
  • Regenerative medicine

Significance to patient care

The goal of Dr. Saris' regenerative medicine research is to optimize treatment for athletes, prevent joint replacement, reduce recovery time and help athletes of all levels to return to their sporting activities.

Professional highlights

  • Adviser on tissue transplantation, Office of Inspector General, U.S. Department of Health and Human Services, 2013-2018
  • IMPACT recognized as a HOT TOPIC, American Academy of Orthopaedic Surgeons, 2016
  • Recipient, Award for Best Research, International Cartilage Regeneration and Joint Preservation Society (ICRS), 2016
  • Conference organizer, Focus Meeting — The Knee, ICRS, 2014
  • President, International Cartilage Repair Society, 2011-2012
  • Chairman, ACL Consensus Group, 2009-2010


Primary Appointment

  1. Consultant, Department of Orthopedic Surgery

Academic Rank

  1. Professor of Orthopedics
  2. Professor of Regenerative Medicine


  1. PhD - Orthopaedics University of Utrecht
  2. Residency - Orthopaedics (Academical Hospital Utrecht Department of Orthopaedics) University of Utrecht
  3. Research Fellowship - Orthopaedics, Cartilage & Biomechanics Laboratory Mayo Clinic Rochester
  4. Medical School University of Amsterdam

Clinical Studies

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