SUMMARY
Peter S. Rose, M.D., studies the surgical treatment of musculoskeletal tumors, with a focus on sarcomas of the spine, pelvis, chest wall and extremities. Dr. Rose investigates tumors that arise in anatomically constrained locations, where achieving wide surgical margins can be challenging. He evaluates multimodal treatment strategies that combine radiotherapy with complex resection and reconstruction. Through his research, Dr. Rose identifies approaches that may provide effective local tumor control while reducing treatment-related complications.
Dr. Rose also examines outcomes after orthopedic oncology surgery. His work includes studies of reconstruction after pelvic and extremity tumor resection, treatment of metastatic spinal disease, and management of pediatric and adult sarcomas. Dr. Rose contributes to prospective treatment studies, retrospective outcomes analyses and multi-institutional consensus efforts. He explores preoperative radiation for soft tissue sarcoma, stereotactic spinal radiotherapy, tumor response in Ewing sarcoma, chordoma management and oncological reconstruction.
Focus areas
- Optimization of sarcoma treatment. Dr. Rose studies how surgery and radiotherapy can be combined for soft tissue and bone sarcomas when anatomical constraints affect tumor control. He evaluates treatment response and clinical outcomes to identify strategies that may maintain effective local control while reducing unnecessary treatments and complications.
- Spine and pelvic oncology. Dr. Rose investigates tumors of the spine and pelvis, including metastatic spinal disease and primary axial malignancies. He studies fracture risk, tumor control, resection and reconstruction. Dr. Rose's research helps care teams choose the right surgical and radiation-based approaches for patients with complex tumors of the spine and other central parts of the body.
- Oncological reconstruction outcomes. Dr. Rose evaluates reconstructive strategies after major tumor resections of the pelvis and extremities. He examines functional and clinical outcomes after procedures such as hemipelvic and proximal humeral reconstruction to determine which approaches provide durable results while limiting morbidity.
- Sarcoma outcomes and response. Dr. Rose studies outcomes in children and adults with sarcoma, including Ewing sarcoma and nonrhabdomyosarcoma soft tissue sarcoma. He uses longitudinal data on clinical outcomes and treatment response to identify prognostic factors and improve treatment planning for patients with rare musculoskeletal cancers.
Significance to patient care
Dr. Rose studies how surgery, radiation and reconstruction can work together to control tumors. His research also looks for ways to reduce complications and loss of function. Dr. Rose's work may help medical teams better understand how patients respond to treatment. It may also help care teams choose risk-reducing surgery and radiation options and improve reconstruction after tumor removal. These advances may help patients stay mobile, avoid treatment that may not be needed and have better long-term outcomes.
Watch Mayo Clinic's documentary Pursuing Possible to learn more about how Dr. Rose and others are using 3D printing to transform surgical care.
Professional highlights
- American Academy of Orthopaedic Surgeons:
- Editor-in-chief, Journal of the American Academy of Orthopaedic Surgeons, 2022-present.
- Deputy editor, Oncology, Journal of the American Academy of Orthopaedic Surgeons, 2012-2021.
- International Society of Limb Salvage:
- Member, Board of directors, 2022-present.
- Best Paper Award, 2024.
- Mayo Clinic:
- Chair, Division of Orthopedic Oncology, Department of Orthopedic Surgery, 2017-present.
- President, Mayo Clinic Officers and Counselors, 2027.
- Distinguished Clinician Award, 2025.
- Founding member, Board of directors, Sacral Tumor Study Group, 2010-present.
- Deputy editor, Sarcoma, Journal of Surgical Oncology, 2013-2021.
- Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences, Orthopedic Surgery, with Franklin H. Sim, M.D., Hamdan Bin Rashid Al Maktoum Foundation for Medical and Educational Sciences, 2017-2018.