The research of Yingxue Ren, Ph.D., focuses on developing and applying novel bioinformatics approaches to translational science to help identify novel disease risk factors and therapeutic targets.
Dr. Ren's specific research interests include:
- Genomic variant analysis using whole-exome and whole-genome sequencing
- Transcriptional profiling of patients and animal models to identify differentially expressed genes, novel exons and transcripts
- Associated gene network and pathway changes related to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia
- Alzheimer's disease. Dr. Ren conducts bulk and single-cell transcriptomics analysis of human brain and animal models to study the pathogenesis of Alzheimer's disease.
- Frontotemporal dementia and Parkinson's disease. She is also focused on identifying genomic single nucleotide variants and complex structural variants associated with frontotemporal dementia and Parkinson's disease.
- Cancer immunotherapy. An additional area of focus involves identification of neoantigens as immunotherapy targets in breast cancer and other diseases.
Significance to patient care
Dr. Ren's research will enable the discovery and validation of novel therapeutic targets for the treatment of neurodegenerative diseases.
- Member, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment, 2021-present
- Member, International Society for Computational Biology, 2017-present