Jacksonville, Florida


Quinones-Hinojosa.Alfredo@mayo.edu Clinical Profile


As the director of the Neurosurgery Brain Tumor Stem Cell Laboratory, Alfredo Quinones-Hinojosa, M.D., studies brain tumors from a surgical, imaging, clinical and basic science perspective. Dr. Quinones-Hinojosa conducts research to predict patient prognosis and discover new methods of delivering effective treatments for brain tumors in diverse populations. He has obtained multiple National Institutes of Health (NIH) grants and holds over a dozen patents. He has started several companies to translate his laboratory work back to the patient.

Focus areas

  • To understand cancer migration and progression in the brain
  • To understand invasive cell populations
  • To uncover novel therapeutic targets to impact tumor progression

Significance to patient care

Dr. Quinones-Hinojosa seeks to improve patient safety, maximize the efficacy of current treatments and advance the development of new therapies for brain tumors.

Professional highlights

  • Dean of research, Mayo Clinic in Florida, 2022-present
  • Monica Flynn Jacoby Chair, Neurologic Surgery, 2022-present
  • Chair, Bioengineering, Technology and Surgical Sciences Study Section, NIH, 2016-present
  • Chair, Surgical branch review, NIH/National Cancer Institute, 2016-present
  • Editorial boards, Journal of Oncology; Annals of Surgical Oncology; World Neurosurgery; World Journal of Stem Cells, 2008-present
  • Investigator of the Year, Mayo Clinic Florida, 2021
  • William J. and Charles H. Mayo Professor IV, 2016


Primary Appointment

  1. Consultant, Department of Neurosurgery
  2. Consultant, Department of Anatomy
  3. Dean, Department of Research

Joint Appointment

  1. Consultant, Department of Otolaryngology - Head & Neck Surgery/Audiology
  2. Consultant, MCF Neuroscience
  3. Consultant, Department of Cancer Biology

Administrative Appointment

  1. Chair, Department of Neurosurgery

Academic Rank

  1. Professor of Neurosurgery


  1. Residency - Neurosurgery University of California San Francisco
  2. Postdoctoral Fellowship - Developmental and Stem Cell Biology University of California San Francisco
  3. Internship - General Surgery University of California San Francisco
  4. Research Fellowship - Bristol-Myers Academic Medicine Fellowship; Studied the use of the intraoperative MRI in brain tumor biopsies. Advisor: Dr. Peter McL. Black. Harvard Medical School
  5. Research Fellowship - Howard Hughes Fellowship; Examined the effects of coenzyme Q10 with nicotinamide; creatine and cyclocreatine (i) in the in vitro rabbit retina preparation, and (ii) in a n in vivo model of focal cerebral ischemia in the rat. Advisors: Dr. Chris Ogilvy and Dr. Ken Maynard. Massachusetts General Hospital and Harvard Medical School
  6. MD - Thesis: Ischemia studies in the rabbit retina in vitro: neuroprotection by metabolic inhibition Harvard Medical School
  7. Research Fellowship - Neurobiology Training Grant Fellowship: Cloned a piece of the ecdysone-steroid receptor gene from the American lobster, Homarus americanus which plays a role in the aggressive behavior. Advisor: Dr. Edward A. Kravitz. Harvard Medical School
  8. Research Fellowship - Ford Baccalaureate Fellowship; Investigated the role of Long Term Potentiation in the Nucleus Accumbens of the Rodent. Advisor: Dr. Joe L. Martinez University of California Berkeley
  9. BA - Psychology, Thesis: Long-term pontentation at the lateral perforant path-nucleus accumbens synapse in the rat in vivo University of California Berkeley
  10. Research Scholar - Medical School Summer Research Program; investigated the role of drugs and lethal injuries in New York City. Advisors: Dr. Kenneth Tardiff and Dr. Peter Marzuk Cornell University
  11. Undergraduate Studies - Transferred core curriculum to the University of California San Joaquin Delta College
  12. BA - Social Sciences and Humanities, Multidisciplinary teaching license Escuela Normal Urbana Federal Fronteriza

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