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Mrinal S. Patnaik, M.B.B.S., is a physician-scientist at Mayo Clinic whose research interests include understanding the development of blood cancers such as chronic myelomonocytic leukemia, myelodysplastic syndrome and acute leukemia. Dr. Patnaik studies genetic and epigenetic changes that can be seen in the blood and bone marrow of people with these diseases. Dr. Patnaik also studies precancerous changes in the blood and bone marrow, a condition called clonal hematopoiesis, and why these precancerous conditions eventually progress to blood cancers.
Dr. Patnaik's research focuses on methods to interrupt the early stages of cancer development before overt neoplasia occurs. By using high-fidelity single-sequencing techniques, Dr. Patnaik and his team are working to define therapeutic vulnerabilities that can lead to clinical trials and effective drug development. He also is helping organize efforts to implement comprehensive clinical genomic sequencing for patients, including whole-exome, transcriptome and whole-genome sequencing.
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