Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
Joao Passos, Ph.D., investigates the role of senescent cells in aging and age-related disease, with a particular focus on the role of mitochondria and telomeres in the process. His work demonstrates how cellular senescence depends on chronic DNA-damage signaling that results from irreparable damage to telomeres. Furthermore, Dr. Passos uncovered a key role for mitochondria in the induction of cellular senescence.
The goal of Dr. Passos' current work is to develop new therapies that target mitochondrial dysfunction to counteract the detrimental impact of senescent cells with aging and age-related diseases.
Dr. Passos' research aims to find new ways to target the aging process, thereby delaying the onset of multiple age-related diseases and increase healthspan. Aging is characterized by multimorbidities and is the major risk factor for all age-related diseases. Dr. Passos subscribes to the idea that decelerating the aging process can delay the onset of multiple diseases and significantly improve the quality of life of older people.
Learn about clinical trials that address specific scientific questions about human health and disease.
Explore all research studies at Mayo Clinic.
See the peer-reviewed findings I have published as a result of my research.
Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.