Rochester, Minnesota




Inna G. Ovsyannikova, Ph.D., studies the genetics of innate and adaptive immune responses to viral and bacterial vaccines. Her interests include vaccine-preventable infectious diseases, particularly the application of mass spectrometry to develop peptide-based vaccines against smallpox, measles, influenza and agents of bioterrorism. Additional research examines gene polymorphisms and predictors of vaccine immune response, viral antigen processing and HLA presentation, and new high-dimensional vaccine studies (transcriptomics, proteomics and others).

Focus areas

  • Immunogenetic mechanisms underlying the immune response variations to pathogens, including measles, mumps, rubella, influenza, vaccinia and anthrax
  • Vaccine nonresponse at various levels of host-pathogen interaction, such as gene polymorphisms (genome-wide association studies and candidate immune response genes, including HLA genes) and immune response levels (innate, humoral and cellular)
  • Antigen processing and presentation and the application of mass spectrometry for developing peptide-based vaccines for measles, smallpox, influenza and agents of bioterrorism
  • High-dimensional studies utilizing platforms such as gene expression microarrays, DNA methylation arrays and next-generation sequencing (mRNA sequencing)

Significance to patient care

The goal of these studies is to use vaccinomics to support future vaccine development. This research provides novel scientific approaches and solutions to vaccine nonresponse, develops a basis for new vaccines designed to overcome genetic restrictions, and gives insights into the functional mechanisms of immunity induced by vaccines.

Professional highlights

  • FOCIS Centers of Excellence trainee award, Federation of Clinical Immunology Societies (FOCIS), 2007, 2012
  • Program Committee Choice Award, Infectious Diseases Society of America for the 48th Annual Meeting, 2010
  • IDSA fellow travel award, Infectious Diseases Society of America (IDSA), 2005, 2006, 2008, 2010
  • Anthrax Vaccine Research Program member, Centers for Disease Control and Prevention, 2004-2010
  • George McCracken Infectious Diseases Fellow, American Society for Microbiology, 2005, 2007


Academic Rank

  1. Professor of Medicine


  1. Fellow - Fellowship (Clinical Pharmacology/Vaccinology), NIH Training Grant in Vaccine Research Group Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Fellow - NIH Training Grant in Allergic Diseases Research Laboratory Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. PhD Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia
  4. MS - Biology (Chemistry minor) Khetagurov North Ossetian State University

Clinical Studies

Learn about clinical trials that address specific scientific questions about human health and disease.

Explore all research studies at Mayo Clinic.


See the peer-reviewed findings I have published as a result of my research.

Review publications.

Mayo Clinic Footer