Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
The research goal of Nadine Norton, Ph.D., is to identify genes and genetic variants that predict which patients will experience pharmacological side effects during cancer treatment and inform appropriate personalized therapeutic intervention. Her research focuses primarily on patients with an aggressive form of breast cancer (HER2-positive) for whom combination chemotherapy and anti-HER2 therapy is potentially lifesaving, but the major clinical side effect is cardiac dysfunction. The long-term goal of Dr. Norton's work is to expand the research to other cancers, to patients with heart failure and to additional clinical side effects such as neuropathy, fatigue and skin toxicities.
Chemotherapeutic agents and targeted therapies are widely used in the treatment of cancer. As major advances are being made to optimize the therapeutic benefit of these drugs, pharmacological side effects associated with them must also be understood and minimized. Heart failure or decline in heart function is a major side effect in some patients. Dr. Norton's goal is to identify genetic variants that predict which patients will develop heart dysfunction and identify therapeutic targets that will enable these patients to continue to receive lifesaving treatment without heart dysfunction.
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