Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. See more conditions.
The main research goal of Georges Mer, Ph.D., is to understand how post-translational modifications (PTMs) regulate the formation of transient protein complexes and enzyme catalysis, with a focus on DNA damage signaling and repair. His team approaches problems from a structural biology perspective and employs a range of complementary biochemical and biophysical techniques, including nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography and cryo-electron microscopy to probe the structure and dynamics of macromolecules. Current studies in his laboratory concentrate on the mechanisms of action of several DNA double-strand break repair proteins, including 53BP1 and BRCA1-BARD1, and on understanding the contribution of chromatin dynamics to the DNA damage response.
Investigations in Dr. Mer's laboratory have relevance to a better understanding of cancer and neurological disorders. This team's focus on basic mechanistic studies may, in the long term, facilitate the development of new therapeutics for cancer treatment.
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