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Robert D. McBane, II, M.D., has a dual research focus in the areas of cardiology and hematology owing to his interest in hemostasis and thrombosis.
Dr. McBane sees patients in Mayo Clinic's Gonda Vascular Center, a multidisciplinary practice devoted to the evaluation and care of patients with vascular diseases. Within the center is a high-volume clinic for patients with thrombotic diseases. In this context, Dr. McBane's specific research interest is the evaluation and management of cancer-related thrombosis, including multicenter randomized controlled trials enrolling patients with cancer and venous thromboembolism.
Cancer-associated venous thrombosis. Dr. McBane has participated in a number of randomized controlled trials focused on the prevention and treatment of cancer associated-venous thromboembolism. These trials include the Apixaban and Dalteparin in Active Malignancy-Associated Venous Thromboembolism (ADAM VTE), CAPRINI and EVE trials. Each of these trials has assessed the efficacy and safety of direct oral anticoagulants compared with low-molecular weight heparin for patients with cancer.
In addition, Dr. McBane participates in ongoing studies on mortality outcomes related to major bleeding or thrombus recurrence for patients who are taking anticoagulants. He has recently completed a study on efficacy and safety related to anticoagulant adherence in the cancer care setting. He also is interested in cancer-associated marantic endocarditis epidemiology and outcomes, including assembly of a retrospective cohort experiencing this complication.
Artificial intelligence and peripheral arterial occlusive disease. Dr. McBane and team are assessing the diagnosis of peripheral arterial occlusive disease. To do this, they are tapping into Mayo Clinic's rich vascular laboratory resources, collaborating with experts in artificial intelligence, and using a Doppler signal and deep neural network analysis. This strategy has been shown to identify patients with peripheral arterial occlusive disease with excellent sensitivity, specificity and overall accuracy.
The team is conducting further studies to determine whether artificial intelligence and deep neural network analysis of Doppler signals can predict important outcomes such as major adverse cardiac events, major adverse limb events and overall mortality.
Each of Dr. McBane's research focus areas drives improvements in patient care and outcomes.
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