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Hu Li, Ph.D., and his research team are focused on systems pharmacology and individualized systems medicine. Dr. Li's team is developing network approaches to studying drug action and side effects in the context of whole-genome regulatory networks. This system can greatly illuminate the understanding of disease mechanisms underlying drugs' modes of action and will ultimately lead to precision medicine for each patient suffering from a devastating disease. His team is currently working to find how a constellation of genes drives disease formation and progression in the form of a regulatory network. The goal is to understand how disease networks are differed among individuals to capture network variations and benefit individualized systems-based therapy.
Patient-specific diagnosis and formulation of the right drug prescription is the major aim in personalized medicine. Understanding disease etiology at the individual regulatory network perspective provides broader insight to prescribe drugs with minimized adverse drug reactions and maximized efficacy. Dr. Li's research results will provide and prioritize potential candidates for experimental validation and clinical application in individualized medicine.
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