Rochester, Minnesota




Jeong-Heon Lee, Ph.D., focuses on deciphering epigenetic mechanisms in the etiology and progression of human diseases. Dr. Lee is an expert in next-generation sequencing (NGS)-based epigenetic technologies and in using this platform to identify disease-specific epigenetic features for early detection, prognosis and treatment stratification.

As director of the Epigenomics Development Laboratory within the Center for Individualized Medicine at Mayo Clinic, Dr. Lee leads the technology development operations and has enabled the optimization and implementation of NGS-based epigenetic technologies using various sample types for research and clinical applications. Dr. Lee also collaborates closely with both basic and clinical scientists using state-of-the-art technologies to elucidate the underlying epigenetic mechanisms in diseases.

Focus areas

  • Development and application of NGS-based epigenetic technologies for research and clinical samples
  • Creation of novel methods and applications using epigenetic technologies for clinical test development
  • Understanding of functional roles of histone modifications in transcriptional processes

Significance to patient care

Epigenetic dysregulation is involved in the etiology and progress of various human diseases. Dr. Lee's research and technology development expertise has led to the establishment of epigenetic-based assays for research discoveries and clinical samples. Drugs targeting aberrant epigenetic changes are used and potentially customized for individualized treatment depending on epigenetic and genetic features of the patient.


Administrative Appointment

  1. Associate Consultant I-Research, Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology

Academic Rank

  1. Assistant Professor of Biochemistry and Molecular Biology


  1. Post Doctoral Researcher - Epigenetics Indiana University School of Medicine
  2. Visiting Student - Biochemistry and Molecular Biology, completed the research for Ph.D. Thesis University of Kentucky
  3. PhD - Biochemistry and Molecular Biology Hanyang University, Seoul, Korea
  4. MSc - Biochemistry Hanyang University, Seoul, Korea
  5. BS - Biochemistry Hanyang University, Seoul, Korea

Clinical Studies

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