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Takahisa Kanekiyo, M.D., Ph.D., studies the pathogenic pathways of age-related neurodegenerative diseases and neurovascular diseases. Specifically, Dr. Kanekiyo focuses on the contributions of apolipoprotein E (APOE) and APOE receptors in Alzheimer's disease (AD) and cerebral amyloid angiopathy. His research aims to determine how aging, sex and APOE isoforms influence cerebrovascular functions as well as disease development and progression using biochemical and molecular approaches through in vitro systems and disease models, with the ultimate goal of developing effective therapies for these diseases. Dr. Kanekiyo also investigates the disease pathogenesis in postmortem brain samples and models through patient-derived induced pluripotent stem cells (iPSCs).
In our aging society an increasing number of patients have neurodegenerative and neurovascular diseases. Dr. Kanekiyo's hope is that his research contributes to a better understanding of the molecular mechanisms in the disease pathogenesis, and provides novel targets to develop effective therapeutic interventions for these diseases.
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