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The research of Robert J. Kahoud, M.D., focuses on the prevention and treatment of brain injury in critically ill infants and children. Patients who have survived critical illnesses such as severe infection, head trauma, respiratory failure or prolonged seizures often have neurological deficits that decrease quality of life. By integrating cellular and molecular experiments in vitro with translational approaches in vivo, Dr. Kahoud seeks to understand how systemic inflammation negatively impacts neural network function, brain development and long-term neurocognitive outcomes. The underlying goal of his research program is to discover novel neuroprotective and neuroregenerative therapies to improve functional outcomes for children in the pediatric intensive care unit.
There is growing evidence demonstrating that reduced mortality in the pediatric intensive care unit as a result of advances in medical care is offset by an increase in morbidity and that children with brain injuries are at especially high risk of poor outcomes. By identifying fundamental mechanisms of brain injury during critical illness, Dr. Kahoud's research will facilitate the discovery of age- and disease-specific therapies to protect and restore normal brain function and reduce morbidity in pediatric patients.
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