The major research focus of William J. Hogan, M.B., B.Ch., relates to nonmyeloablative hematopoietic stem cell transplantation. His specific interests include evaluation of novel post-grafting immunosuppressive regimens to determine safe and effective combinations to achieve mixed chimerism with minimal toxicity.
Other avenues of investigation include the use of nonmyeloablative transplantation as a platform for adoptive immunotherapy to develop a graft-versus-solid organ effect for kidney transplantation or, conversely, to develop tolerance.
- Nonmyeloablative transplantation. Dr. Hogan recently pursued a research fellowship in transplantation biology with Rainer Storb, M.D., at the Fred Hutchinson Cancer Research Center (Fred Hutch) in Seattle, investigating nonmyeloablative regimens in a canine model. The canine model has provided the foundation for the current nonmyeloablative transplantation techniques in humans at Fred Hutch.
Significance to patient care
Dr. Hogan is actively involved in developing nonmyeloablative transplantation techniques for clinical use, and is particularly interested in developing such a strategy for patients with myelofibrosis (agnogenic myeloid metaplasia).