Location

Rochester, Minnesota

Contact

Herrmann.Sandra@mayo.edu Clinical Profile

SUMMARY

The research interests of Sandra M. Herrmann, M.D., are focused on nephrotoxicity of cancer immunotherapies and mechanisms of hypertensive kidney disease. In particular, Dr. Herrmann's studies of renovascular disease focus on pathways of inflammation and injury in ischemic nephropathy and the potential for repair of the injured kidney using regenerative medicine.

Focus areas

  • Regenerative medicine. Dr. Herrmann's research involves the application of mesenchymal cell therapy in preclinical models of hypertensive kidney disease oriented toward translation to patients with chronic kidney disease in the setting of hypertension and occlusive renovascular disease. She is interested in optimization of stem cell function using hypoxia preconditioning and further studying its effects on paracrine mechanisms of mesenchymal stem cell-derived extracellular vesicles.
  • Renovascular disease. Dr. Herrmann is interested in the mechanisms and physiopathology of atherosclerotic renovascular disease. She is studying the disease process and the effects of ischemia-reperfusion injury during percutaneous revascularization.
  • Onco-nephrology. Dr. Herrmann's research is focused on kidney diseases caused by hematologic diseases and on nephrotoxicity of cancer therapeutic agents such as immune checkpoint inhibitors, chimeric antigen receptor (CAR)-T cell therapy and other targeted cancer therapies.

Significance to patient care

Dr. Herrmann's goal is to improve the outcomes of patients with chronic kidney disease. Through innovative research identifying novel regenerative medicine therapies, Dr. Herrmann's work will aid in recovery from kidney disease (or at least stabilization of kidney function) in order to avoid or delay renal replacement therapy such dialysis or kidney transplantation.

In addition, identifying and characterizing nephrotoxicity of cancer therapies helps to understand the etiology of the renal adverse event of a patient, which may help with management of the relevant side effect profile and timely recognition of adverse effects in patients undergoing cancer treatment.

Clinical Studies

See my clinical studies

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

Primary Appointment

  1. Consultant, Division of Nephrology & Hypertension, Department of Internal Medicine

Academic Rank

  1. Associate Professor of Medicine

EDUCATION

  1. Fellow Nephrology Research Fellow - Mayo Clinic
  2. Fellow Nephrology Fellowship - Mayo Clinic
  3. Residency - Post-graduate clinical education in the United States. Internal Medicine Residency -Mayo Clinic
  4. Fellow - Post-graduate clinical education in the United States. Mayo Graduate School of Medicine, Fellowship: Research Fellow-Laboratory of Physiology and Biophysicis
  5. Post-graduate clinical education in Brazil. Internal Medicine/Nephrology residency-fellowship program (combined program). Hospital Sao Lucas da PUCRS.
  6. MD Medical school: Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)
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BIO-20434761

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