Rochester, Minnesota


Guo.Ruifeng@mayo.edu Clinical Profile


Ruifeng (Ray) Guo, M.D., Ph.D., is a diagnostic pathologist specializing in dermatopathology, general surgical pathology and ophthalmic pathology. His clinical and research interests are in the areas of disease diagnosis, exploration of markers and clues to predict disease severity, and targeted therapy.

Dr. Guo specializes in skin diseases and conjunctival diseases, including tumors and inflammatory conditions. He is also heavily involved in Mayo Clinic's intraoperative frozen section service for patients undergoing surgical treatment, and works with highly diverse types of diseases in surgical pathology.

Focus areas

  • Consultative service in complex and rare diseases in the membranes of the eye (conjunctiva) and the skin, as well as diagnostic service in oncologic and nononcologic surgical pathology
  • Genomic and transcriptomic profiling of cutaneous and conjunctival neoplasms, including melanoma and its precursors, diagnostically challenging tumors, and clinically aggressive tumors
  • Tumor microenvironment, including tumor supporting tissues (stroma) and infiltrating immune cells, in various melanoma subtypes and clinically challenging mucocutaneous tumors
  • Immune microenvironment in subacute and chronic inflammatory skin diseases
  • Diagnostically challenging mucocutaneous diseases

Significance to patient care

Dr. Guo's clinical practice is directly related to the diagnosis and treatment of a variety of diseases, with a focus on clinically challenging and complex conditions. His research is closely aligned with his clinical practice, with the aims of providing better diagnostic modalities, prognostic parameters and therapeutic targets that drive advances in patient care.

His ultimate goal is to explore innovations based on cutting-edge concepts and technologies in biomedical sciences that will most effectively improve patient care.


Primary Appointment

  1. Consultant, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology
  2. Vice Chair of Work Flow, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology

Academic Rank

  1. Assistant Professor of Dermatology
  2. Assistant Professor of Laboratory Medicine and Pathology


  1. Fellowship - Dermatopathology Fellowship in Department of Dermatology Dermatopathology, Department of Dermatology
  2. Fellowship - Surgical Pathology in Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, Department of Laboratory Medicine and Pathology
  3. Chief Resident - Department of Pathology University of Oklahoma Health Sciences Center
  4. Resident - Department of Pathology University of Oklahoma Health Sciences Center
  5. Postdoctoral Research Fellowship - Science Park Research Division and Department of Carcinogenesis University of Texas MD Anderson Cancer Center
  6. Ph.D. - Molecular Carcinogenesis and Molecular Pathology University of Texas Graduate School of Biomedical Sciences and MD Anderson Cancer Center
  7. Master of Science - Physician Scientist Training Program College of Medicine of Zhengzhou University
  8. MD Henan Medical University

Clinical Studies

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