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Fabienne C. Fiesel, Ph.D., conducts research focused on understanding the cellular biological mechanisms of neurodegenerative disorders with the goal of developing new biomarkers and disease-modifying therapeutics. At the heart of her interest is a fundamental protective pathway that is disrupted in familial forms of early-onset Parkinson's disease. This pathway ensures the elimination of worn out or dangerously damaged mitochondria in healthy cells. Dr. Fiesel's research primarily uses cell culture models and a combinatorial approach of molecular biology, biochemistry and imaging.
Dr. Fiesel's research aims to generate specific biomarkers for mitochondrial quality control to stratify patients for clinical trials and predict targeted therapeutics. Preclinical tool compounds will be useful for target validation with the ultimate goal to treat and cure disease.
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