The research of Mackram F. Eleid, M.D., focuses on improving the understanding, diagnosis and treatment of structural and ischemic heart diseases. Specific interests include characterization and identification of therapeutic targets for hemodynamic subsets in valvular heart diseases, including low-gradient severe aortic stenosis, through a combination of invasive hemodynamic cardiac catheterization and cardiac imaging clinical research studies. As an interventional cardiologist, Dr. Eleid has special interest in percutaneous approaches to treatment of a variety of structural heart diseases. Within ischemic heart diseases, Dr. Eleid has special interest and expertise in acute coronary syndromes, including spontaneous coronary artery dissection (SCAD), with focuses on improving understanding of the pathophysiology, disease identification and treatment.
- Aortic stenosis. Dr. Eleid focuses on improving the understanding and treatment of hemodynamic subsets in aortic stenosis, including paradoxical low-flow, low-gradient aortic stenosis, through invasive hemodynamic catheterization studies, echocardiography and clinical outcomes studies.
- Transcatheter aortic valve replacement. Dr. Eleid has interest in optimizing treatment approaches in percutaneous transcatheter aortic valve replacement, a novel, minimally invasive treatment for aortic stenosis.
- Spontaneous coronary artery dissection (SCAD). Dr. Eleid works to improve understanding of the pathophysiology, diagnosis and treatment of SCAD through clinical research studies.
- Percutaneous treatment of structural heart disease. Dr. Eleid studies the effects of percutaneous treatment of structural heart diseases, including mitral stenosis, mitral regurgitation and paravalvular prosthetic regurgitation.
- Hemodynamic evaluation of structural heart disease. Dr. Eleid studies the pathophysiology and clinical impact of hemodynamics in structural heart diseases including valvular heart disease and cardiomyopathies.
Significance to patient care
Through better understanding of disease pathophysiology, specific markers of risk and treatment responses, Dr. Eleid's work can improve the diagnosis of structural and ischemic heart diseases and optimize outcomes for patients with these conditions. Introducing novel diagnostic and therapeutic modalities in the cardiac catheterization laboratory for patients with complex cardiac diseases enhances patient care.
- Finalist, American College of Cardiology Young Investigator Award, Physiology, Pharmacology and Pathology category, American College of Cardiology Scientific Sessions, 2013