Divyanshu (Div) Dubey, M.B.B.S., studies central and peripheral autoimmune neurological conditions. This includes searching for novel biomarkers in serum and cerebrospinal fluids of patients with autoimmune and paraneoplastic neurological syndromes. Dr. Dubey's research also focuses on analyzing clinical and radiologic features of autoimmune neurological disorders that can aid in early diagnosis and guide treatment.
Dr. Dubey recently published research in the New England Journal of Medicine in which a novel paraneoplastic autoantibody was identified. The 2019 article, "Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis," was contributed to equally by Dr. Dubey, Caleigh Mandel-Brehm, Ph.D., Michael R. Wilson, M.D., and Sean J. Pittock, M.D.
- Autoantibody biomarkers. Dr. Dubey's laboratory research focuses on identifying novel autoantibodies for diagnosis of autoimmune or paraneoplastic neurological syndromes. He also evaluates the clinical and oncologic associations of previously described neural-specific antibodies.
- Epidemiology. Dr. Dubey is working to establish accurate incidence and prevalence of autoimmune neurological disorders through population-based studies.
- Autoimmune epilepsy. Dr. Dubey works to evaluate the role of autoimmunity among patients with epilepsy of unknown etiology. He also contributes to creating and validating predictive models for diagnosis and management of autoimmune epilepsy.
- Paraneoplastic neuropathies. An additional area of focus for Dr. Dubey is studying and describing clinical and electrodiagnostic phenotypes of paraneoplastic neuropathies.
Significance to patient care
The goal of Dr. Dubey's research is to improve diagnostic and treatment strategies for patients with autoimmune disorders affecting the central nervous and peripheral nervous systems.
- Recipient, Arthur K. Asbury Inflammatory Neuropathy Award, Peripheral Nerve Society, 2018
- Recipient, Epilepsia Clinical Science Prize, International League Against Epilepsy, 2018
- Recipient, Fred Baskin Young Investigator Award, UT Southwestern Medical Center, 2015