Research efforts include the testing of novel compounds for the acute and prevetive treatment of migraine and cluster headache. Also, I am involved in basic studies to determine the underlying central nervous system abnormalities involved in the development of chronic daily headache. In collaboration with colleagues in Neurosurgery and Anasthesia/Pain, we are conducting clinical trials to evaluate the safety and efficacy of peripheral neurostimulation devices for chronic head pain/ chronic migraine. I am also involved in the evaluation of new compounds for the acute treatment of ischemic stroke. The stroke team at MCS is also conducting studies using novel agents for the treatment of acute stroke.