Location

Rochester, Minnesota

Contact

DeLanghe.Stijn@mayo.edu

SUMMARY

Stijn P. De Langhe, Ph.D., is interested in lung regeneration. Research in his lab is focused on lung stem cell niche interactions in pulmonary fibrosis, chronic obstructive lung disease (COPD), asthma and acute respiratory distress syndrome (ARDS).

Focus areas

The goal of Dr. De Langhe's research is to define the molecular mechanisms underlying lung development and to determine how these mechanisms can be harnessed to improve repair and regeneration in the lung. His team seeks to clarify the mechanistic basis of bidirectional signaling between lung stem cells and their niche, which informs lung stem cell fate decisions, including choices between quiescence or proliferation, self-renewal or differentiation, migration or retention, and cell death or survival.

Dr. De Langhe expects his inquiries into the molecular mechanisms underlying adult lung epithelial regeneration to serve as a framework that will assist his lab to understand how aberrant activation of normal developmental processes results in human lung diseases. He and his colleagues are primarily interested in transferring their knowledge about lung development to repair and disease processes in the adult lung. All their data is indicating that adult lung cells hijack the pathways important for lung development to respond to injury.

Significance to patient care

Dr. De Langhe's research into the molecular mechanisms underlying adult lung epithelial regeneration is indicating how aberrant activation of normal developmental processes results in human lung diseases such as idiopathic pulmonary fibrosis (IPF), COPD and ARDS.

Professional highlights

  • Chair, 2nd Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference, Fusion Conferences, 2022
  • Chair, Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference Fusion Conferences, 2019

PROFESSIONAL DETAILS

Administrative Appointment

  1. Senior Associate Consultant II-Research, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine

EDUCATION

  1. Post-Doc Childrens Hospital Los Angeles, USC Keck School of Medicine
  2. PhD - Site: Childrens Hospital Los Angeles, The Saban Research Institute Developmental Biology Program (1999-2005) Dissertation: Role of FGF and Wnt signaling in mesenchymal differentiation during lung development. Mentor: Saverio Bellusci, Ph.D Granting University: Ghent University, Belgium. Site: Childrens Hospital, Los Angeles, CA
  3. Masters - Masters in Biotechnology/Biochemistry. Dissertation: Molecular dissection of human cadherin complexes by use of the LexA yeast two hybrid system. Mentor: Prof. Dr. F. van Roy Ghent University, Belgium
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