Rochester, Minnesota




The research mission of Shigao Chen, Ph.D., is to provide innovative ultrasound solutions to meet critical clinical needs of patients. His research program is mainly focused on developing novel ultrasound imaging technologies for the quantitative evaluation of various diseases with high accuracy. Special emphasis is given to translational research that brings new techniques from bench to bedside to improve patient care.

The Comb-push Ultrasound Shear Elastography (CUSE) technology developed by Dr. Chen and colleagues has been licensed by leading ultrasound companies, implemented on clinical ultrasound scanners and used around the world to benefit patients. Dr. Chen has many patents, and his research has been supported by competitive grants from the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Biomedical Imaging and Bioengineering.

Focus areas

  • Shear wave elastography. The CUSE technology uses multiple push beams spaced out like a comb to produce shear waves for high signal-to-noise ratio and fast 2-D shear wave imaging. Mechanical vibration is used in another technology to generate shear waves deep within the body for noninvasive liver fibrosis staging in obese patients.
  • Microvessel imaging. High frame rate ultrasound imaging combined with novel processing algorithms are used to image microvessels that are less than 50 microns in size. These technologies have a wide range of medical applications in the diagnosis and treatment evaluation of cancers and inflammatory diseases, as well as functional imaging of the brain and spinal cord.
  • Therapeutic ultrasound. The interaction of ultrasound with cells and micro- or nanoparticles can be leveraged for augmented therapy and targeted or localized drug release to reduce systematic side effects.

Significance to patient care

Ultrasound is safe — it has no ionizing radiation — cost-effective and widely accessible. Therefore, ultrasound solutions with validated efficacy have high positive impacts for the delivery of patient care.

Professional highlights

  • Vice chair, Technical Standards Committee, American Institute of Ultrasound in Medicine (AIUM), 2016-2019
  • Vice chair, Elastography Interest Group, AIUM, 2016-2018
  • Fellow, AIUM, 2015-present
  • Member, Ultrasound Shear Wave Speed Technical Committee, Quantitative Imaging Biomarkers Alliance, 2012-present

Clinical Studies

See my clinical studies


See my publications


Administrative Appointment

  1. Associate Consultant II-Research, Department of Physiology & Biomedical Engineering
  2. Associate Consultant II-Research, Department of Radiology

Academic Rank

  1. Associate Professor of Biomedical Engineering
  2. Professor of Radiology


  1. PhD Biophysics/Biophysical Sciences, Biomedical Engineering Track, Programs, Mayo Graduate School, Mayo Clinic College of Medicine
  2. MS Biomedical Engineering, Tsinghua University
  3. BBA Business Administration, Tsinghua University
  4. BS Biomedical Engineering, Tsinghua University

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