Rochester, Minnesota


Asirvatham.Samuel@mayo.edu Clinical Profile


Samuel J. Asirvatham, M.D., is an electrophysiologist at Mayo Clinic's campus in Rochester, Minnesota. After completing medical school at the Christian Medical College in Vellore, India, his internship was at the Columbia University Medical Center in New York City.

Following residency and chief residency at the University of Wisconsin-Madison, he did his clinical cardiac and electrophysiology training at the University of Oklahoma near Oklahoma City.

Dr. Asirvatham is currently a professor of medicine in the Division of Cardiovascular Diseases within the Department of Internal Medicine and a professor of pediatrics in the Division of Pediatric Cardiology within the Department of Pediatric and Adolescent Medicine. He is a consultant in cardiac electrophysiology.

He is also program director for the Clinical Cardiac Electrophysiology Fellowship and director of strategic collaboration for the Center for Innovation at Mayo Clinic, Rochester, Minnesota.

Focus areas

Dr. Asirvatham's research and innovation interests include:

  • Development of a percutaneous epicardial system to close the left atrial appendage
  • Renal nerve stimulation for the treatment of neurocardiogenic syncope
  • Development of a novel circuit to prevent coagulum formation during radiofrequency ablation procedures
  • Specifically designed and created tools to allow electrophysiology mapping and ablation through the veins of the central nervous system to treat seizures and other central nervous system disorders

Significance to patient care

One of the primary goals of Dr. Asirvatham's clinical research is improving quality of life and patient care.

Current research projects include solutions to neurocardiogenic syncope by utilizing pacing in the renal vein to increase blood pressure and prevent syncope; epilepsy and other central nervous system disorders by mapping and ablation of the central nervous system; and stroke and thromboembolic events in atrial fibrillation patients and atrial fibrillation patients after ablation through left atrial ligation/obliteration and coagulum reduction, and investigating the possible link of stroke events with cardiac device leads.

Professional highlights

  • James M. and Lee S. Vann Professor of Cardiovascular Diseases, 2021


Primary Appointment

  1. Consultant, Division of Heart Rhythm Services, Department of Cardiovascular Medicine
  2. Chair for Education, Division of Heart Rhythm Services, Department of Cardiovascular Medicine
  3. Vice Chair for Innovation, Department of Cardiovascular Medicine

Joint Appointment

  1. Consultant, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine
  2. Consultant, Department of Physiology & Biomedical Engineering
  3. Consultant, Department of Anatomy

Academic Rank

  1. Professor of Medicine
  2. Professor of Pediatrics


  1. Fellow - Electrophysiology/Pacing Mayo Clinic in Rochester
  2. Fellow - Cardiology University of Oklahoma, Oklahoma City
  3. Chief Resident University of Wisconsin, Madison
  4. Resident University of Wisconsin, Madison
  5. Internship St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY
  6. House Officer - (Nagari, India) CSI Hospitals, Christian Medical College
  7. Post-Grad - (Vellore, India) Christian Medical College
  8. MB BS - (Vellore, India) Christian Medical College

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