Rochester, Minnesota


ansell.stephen@mayo.edu Clinical Profile


The research of Stephen M. Ansell, M.D., Ph.D., is focused on understanding the biology of B-cell malignancies (including Hodgkin's lymphoma Waldenstrom's macroglobulinemia and non-Hodgkin's lymphoma) and to explore the role of the tumor microenvironment in supporting cancer cell growth and survival. The goal of his program is to translate this knowledge into new treatment approaches for patients.

Focus areas

  • T-cell activation and T-cell exhaustion. Dr. Ansell's lab studies why the immune response to cancer is suppressed.
  • Tumor-associated macrophages and monocytes. This research seeks to understand the role of phagocytic cells in the tumor.
  • The bone marrow microenvironment in Waldenstrom's macroglobulinemia. Dr. Ansell's lab is studying the role of cytokines and immunologically active signals in activating or suppressing tumors and promoting immunoglobulin production.

Significance to patient care

Dr. Ansell's research has contributed to the use of immune checkpoint therapy in lymphomas. He led the clinical trial that resulted in the approval of nivolumab (Opdivo) for Hodgkin's lymphoma.

Professional highlights

  • Dorotha W. and Grant L. Sundquist Professorship in Hematologic Malignancies Research, 2022
  • Lifeblood of Healthcare Award, Leukemia & Lymphoma Foundation, 2017
  • Chair, Scientific Advisory Committee of the International Waldenstrom's Macroglobulinemia Foundation, 2015-present
  • Editorial board, Journal of Clinical Oncology, 2015-present
  • Member, Scientific Committee of the Leukemia & Lymphoma Society, 2015-present
  • Chair, Mayo Clinic Lymphoma Group, 2014-present
  • Associate editor, American Journal of Hematology, 2011-present


Primary Appointment

  1. Consultant, Division of Hematology, Department of Internal Medicine
  2. Chair of Faculty Development and Recruitment, Division of Hematology, Department of Internal Medicine
  3. Enterprise Deputy Director and Senior Deputy Director, Midwest, Mayo Clinic Comprehensive Cancer Center

Administrative Appointment

  1. Chair, Division of Hematology, Department of Internal Medicine

Academic Rank

  1. Professor of Medicine


  1. Fellow - Hematology/Oncology Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. Resident - Internal Medicine Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. Registrar - Internal Medicine University of the Witwatersrand
  4. Fellow - Medical Oncology University of Pretoria
  5. PhD - Medical Sciences University of Pretoria
  6. Resident - Internal Medicine University of Pretoria
  7. Diploma - Diploma in Tropical Medicine & Hygiene University of the Witwatersrand
  8. Internship - Internal Medicine/Surgery University of the Witwatersrand
  9. MB ChB - Medicine and Surgery University of Pretoria

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