Clinical Trials
Below are current clinical trials.
267 studies in Pulmonary and Critical Care Medicine Research (all studies, either open or closed).
Filter this list of studies by location, status and more.
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Rochester, Minn.
The purpose of this study is to evaluate intrapleural administration of Adenovirus-Delivered Interferon Alpha-2b (rAd-IFN) in combination with Celecoxib and Gemcitabine in patients with histologically confirmed Malignant Pleural Mesothelioma (MPM) who have failed a minimum of 1 treatment regimen and a maximum of 2 treatment regimens, 1 of which must have been an anti-folate and platinum combination regimen.
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Rochester, Minn.
The purpose of this study is to identify patients preference of one mode of noninvasive ventilation (BPAP-ST) over another (IPAP) in patients being treated for respiratory issues related to neuromuscular disease.
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Rochester, Minn.
The purpose of this study is to provide evidence of the safety and effectiveness of inhaled mannitol for adult patients with cystic fibrosis.
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Rochester, Minn.
The purpose of this study is to determine how many rounds of plasma exchange are required for maximal decrease in measles antibodies and how long it may last, for the successful use of measles virus cancer therapy.
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Rochester, Minn.
The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.
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Rochester, Minn.
The primary purpose of this study is to see how GLPG1690 works together with current standard treatment on lung function and IPF disease in general. The study will also investigate how well GLPG1690 is tolerated (side effects).
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Rochester, Minn.
This phase I clinical trial investigates the side effects and the best dose of local (intrapleural measles virus therapy in treating patients with malignant pleural mesothelioma (MPM). The investigators anticipate that the intrapleural of the vaccine strain measles virus will enable the virus to specifically infect and kill cancer cells and spare, without damaging normal cells. Furthermore, the investigators expect the measles virus to trigger an anti-tumor immune response which will result in additional destruction of the tumor by immune cells.
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Jacksonville, Fla.
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
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Rochester, Minn.
Neonates who are born prematurely or who experience respiratory problems shortly after birth are at risk for bronchopulmonary dysplasia (BPD). BPD is the most common pulmonary morbidity in preterm neonates and affects approximately. Babies first diagnosed with BPD receive intense supportive care in the hospital, usually in a neonatal intensive care unit (NICU), where the length of stay can range from several weeks to a few months. Even after leaving the hospital, a baby might require long-term diuretic, bronchodilator or oxygen therapies at home. Although most children with BPD are weaned from supplemental oxygen by the end of their first year, a few with serious cases may need oxygen for through early childhood and beyond. Advances in perinatal care, changes in health care economics and research suggesting a negative impact of prolonged hospitalization on development of the preterm newborn have influenced discharge practices for neonates with BPD. The home environment increasingly has been recognized as the optimal setting for medically stable, technology-assisted neonates to receive the complex and demanding care they require.The goal of the proposed study is to determine whether a newly developed, highly-miniaturized oxygen saturation-monitoring instrument might be of use in the care of neonates with BPD who will transition from the neonatal intensive care unit (NICU) to the home environment.
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Rochester, Minn.
The purpose of this study is to identify potential pathogens in parapneumonic effusions associated with community acquired pneumonia and health care acquired pneumonia.