Aleksandra Kukla, M.D.

The KPMP study protocol describes the cohort study of adult men and women participants with AKI and CKD, including the study design, visit schedule, study procedures, data collection, study outcomes and data management. Given the risk of potential complications from kidney biopsy, the protocol also reviews the published literature of biopsy complication rates and risk factors for adverse events, which informed the study inclusion/exclusion criteria and study design. In addition, it describes the safety and monitoring procedures to be implemented at all Recruitment Sites as KPMP holds ethical and participant safety considerations paramount. Finally, the protocol summarizes tissue processing, data quality control/assurance, return of results, and participant engagement after enrollment.

The purpose of this study is to compare pro-inflammatory and pro-fibrotic cytokines expression in 40 Living kidney donors (LKDs), stratified by low PRAT thickness (<10 mm) and high PRAT thickness (>14 mm) identified on the pre-donation CT scan.

This study aims to measure the percentage of time spent in hyperglycemia in patients on insulin therapy and evaluate diabetes related patient reported outcomes in kidney transplant recipients with type 2 diabetes. It also aimes to evaluate immunosuppression related patient reported outcomes in kidney transplant recipients with type 2 diabetes.