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Clinical Studies

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  • Adolescent Perspectives on WES and WGS Rochester, Minn.

    The purpose of this study is to examine adolescents' experiences with and perspectives on current practices in Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS), current strengths and challenges of the process of WES and WGS and receiving results, and suggestions for the future. Semi-structured interviews will be conducted with adolescents who have had WES or WGS to generate this unique dataset.
  • Characterizing healthcare provider and patients experiences with implementing genomic medicine in a Federally Qualified Health Center Rochester, Minn.

    The purpose of this study is to characterize healthcare provider experiences caring for Latino/a patients receiving PRS in a Federally Qualified Health Center (FQHC) in Phoenix, Arizona, with a contextual emphasis on the setting, social determinants, and normative influences that underpin how healthcare providers integrate genomic medicine into patient care. Additionally to characterize Latino/a patient experiences receiving PRS in a FQHC in Phoenix, Arizona, with a contextual emphasis on the social determinants that shape to the effectiveness and utility of genomic medicine for them, and to disseminate our findings with FQHC leaders through the Arizona Alliance for Community Health Centers in order to generate a conversation on building capacity for healthcare providers to integrate genomic medicine within under-resourced healthcare settings.
  • Exploring the Experiences of Cancer Patients and Their Decisions About Sharing Genetic Cancer Screening Information with Family Members (Intercept 2) Rochester, Minn.

    The purpose of this study is to characterize the beliefs and attitudes of cancer patients who received a positive result from a genetic cancer screen as part of the Mayo Clinic Intercept study (IRB#18-000326, PI: Samadder). This data will be collected using semi-structured, one-on-one interviews.
  • Nurse Opinions on the Monitoring and Prediction of Burnout Rochester, Minn.

    The purpose of this study is to characterize opinions of nurses and nurse leadership regarding current and theoretical applications of digital technologies in the context of nursing burnout. To explore if nurses in various organizational roles will share their perspectives on nursing burnout, workplace monitoring, and digital methods for predicting, tracking, and treating symptoms of burnout.
  • Patient Experiences of Neuromodulation for Epilepsy Rochester, Minn.

    The primary purpose of this study is to understand how epilepsy patients think about neuromodulation in relation to concepts of neuroexceptionalism and the self.
  • Return of Actionable Variants Empirical (RAVE) Study (RAVE) Rochester, Minn.

    The purpose of this study is to conduct a genomic medicine implementation project to establish mechanisms for return of actionable findings from targeted sequencing of ~109 disease-relevant genes and genotyping of select polymorphisms in a large study setting (eMERGE III consortium). A primary focus of the Mayo group will be on two common actionable genetic disorders–familial hyperlipidemia (FH) and familial colorectal cancer (CRC).
  • The electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment (eMERGE IV) Rochester, Minn.

    The electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment Study is a multisite study funded by the National Human Genome Research Institute (NHGRI) to investigate the clinical utility of polygenic risk scores for common conditions in adults and children. eMERGE researchers aim to learn about how people’s family history and genetic makeup affect their risk of developing common conditions such as heart disease, diabetes, and cancer, and about how to use this information to help them reduce their risk. The study will recruit 25,000 participants from around the country, including groups who are underrepresented in biomedical research.

    Each participant will provide a biospecimen for genetic testing and fill out surveys about personal and family health history. Participants will receive a Genome Informed Risk Assessment (GIRA) report that includes their estimated risk for common conditions based on genetic testing results, clinical variables, and family history. The GIRA report will be uploaded to the participant's electronic health record and is meant to help participants and providers interpret risk for common conditions. A subset of participants will receive their results from a member of the study team in-person or by a virtual appointment.
  • The Mayo Clinic Opinion Panel (MCOP) Rochester, Minn.

    The purpose of the Mayo Clinic Opinion Panel is to constitute a large sample of individuals who consent to provide periodic feedback regarding their opinions, beliefs, attitudes, concerns, and overall personal dispositions toward specific applications of artificial intelligence and other issues of data stewardship that arise as Mayo Clinic continues to expand its data platform.
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