Matt J. Ziegelmann, M.D.

The purpose of this study is to create a dataset of outcomes for common men’s health urologic procedures to address the frequency of complications within 30 days following the procedure and determine associations with patient and procedural characteristics. Also, for patients with preoperative pain, we seek to assess frequency of improvement in pain, defined as a reduction in pain of 50% or greater as compared to preoperative pain and to identify predictive clinical and patient features, and for patients undergoing men’s health procedures with sexual health function concerns, we seek to assess improvement in sexual function following intervention, measured by patient reported data.

This is a single-center, prospective, single-cohort unblinded pilot study that will enroll 10 patients undergoing radical prostatectomy for prostate adenocarcinoma. The studies will be carried out through collaboration between the primary investigator teams in the departments of urology and radiology. The goal is to determine whether there is additional utility to using vibroelastography, a noninvasive ultrasound technique to evaluate for the presence of tissue fibrosis, in conjunction with standard penile duplex Doppler ultrasound to assess erectile function (recovery) after prostate cancer surgery.  Potential study participants will be identified during consultation for prostate cancer in the urology clinic at Mayo Clinic in Rochester, MN. Given that we perform approximately 300-500 prostatectomies at Mayo Clinic annually, we anticipate a large pool of potential participants to recruit for the current study protocol.

The purpose of this study is to collect real-world data (RWD) to gain a more in-depth knowledge of the treatment of Peyronie's Disease (PD) to evaluate the management of PD.

The purpose of this study is to determine if elevations in oxidative stress, as measured by oxidation-reduction potential (ORP), can distinguish between semen samples from men with abnormal semen parameters from those with normal semen parameters. Static ORP (sORP) results, measured by the MiOXSYS System- a novel technology, will be compared to the current World Health Organization (WHO) semen analysis parameters.

The purpose of this study is to determine the effects of liposomal bupivacaine vs lidocaine/bupivacaine mixture in patients’ undergoing surgical placement of a penile prosthesis.

This clinical trial is designed to assess the safety, dosing, and preliminary efficacy of a novel penile traction device on correcting deformities relating to Peyronie's disease, a condition which results in penile curvature and length loss. The trial is designed as a randomized, placebo-controlled study with men randomized to receiving no therapy or penile traction therapy 30 minutes once, twice, or three times daily. The study will occur over a 3 month period, after which an open label phase for 3 months will be conducted. Final assessments for adverse effects will also be assessed at 9 months.

The purpose of this study is to create a penile prosthesis registry to be maintained by Mayo Clinic to greatly enhance the quality of published literature, provide more reliable expectations for patients seeking surgery, allow surgeons to compare their outcomes against national and expert standards, and potentially serve as an FDA-reference standard for seeking new device indications.

The purpose of this study is to provide comprehensive genetic profiling of Peyronie's Disease (PD) patients, discover candidate genes associated with the disease, and to compare the identified candidate genetic mutations/variations with familial and non-familial cases.

The purpose of this study is to assess penile length pre- and post-completion of RestoreX® traction therapy compared to control groups (no treatment) among men with type II diabetes.