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Time Longitudinal Study of the Microbiome in Colorectal Cancer Subjects
The purposes of this study are to characterize the microbes that are causal of colorectal cancer and those that are merely conditions of the tumor. This will be accomplished by comparing the microbiomes before and after resection. Secondly, to pilot a study to differentiate between the effect of resection versus the effect of tumor removal by comparing microbiomes in two cohorts: colorectal cancer patients and controls from benign colon resection. Finally, to understand what confers community-level microbial stability or resilience in a colorectal cancer patient. This pilot study will be accomplished by sampling stool samples from patients longitudinally, and then using advance bioinformatics and statistical learning techniques to identify features predictive of gut microbial ecological properties.