Nandita Khera, M.D., M.P.H.

The purpose of this study is to analyze the financial difficulties experienced by patients undergoing treatment for multiple myeloma (MM) and chronic lymphocytic leukemia (CLL). It is composed of a patient survey (n=250), a physician survey (n=100), and a practice survey completed by each site enrolling patients onto this study. A subset of enrolled patients (n=35) will be invited to participate in an optional second telephone interview (Appendix D). This study will measure the prevalence of patient-reported financial difficulty, specific financial burdens and resources currently available to patients and from practices to assist with patient financial navigation.

The primary purpose of this study is to learn more about what makes stem cell transplants work well, such as determining the following:

• How well recipients recover from their transplant;
• How recovery after a transplant can be improved;
• How access to transplant for different groups of patients can be improved;
• How well donors recover from the collection procedures.

The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period.

The purpose of this study is to collect pilot data to determine levels of physical activity (PA) among HCT patients and caregivers, and to assess hypothetical interest in a dyad-based, technology-enhanced PA intervention for HCT patients and caregivers.

The purpose of this study is to assess the level of financial and health insurance literacy and financial distress in cancer patients coming to the infusion center by analyzing the correlation amongst these outcomes, as well assessing their association with baseline sociodemographic and disease/ treatment factors.

The purpose of this study is to determine the set of assessments and biomarkers that could together constitute a robust and valid composite health risk model for accurate personalized estimation of one year NRM.

The purpose of the study is to examine the agrrement in perception of finacial hardship (FH) and the perceived stress in patients with multiple myeloma (MM) and their caregivers (CG). Additionally, we will describe protective buffering/emotional disclosure in patients with MM and their CGs and examine their association with FH, and perceived stress.

The purpose of this study is to develop digital, personal narrative stories about hematopoietic stem cell transplantation (HCT) with a sample of HCT caregivers. 

The study is testing the effectiveness of digital story intervention in caregivers of patients who have recently undergone transplant for hematopoietic cell malignancies. Research has shown that viewing presentation of HCT stories from individuals who have similar experiences with their diagnosis and treatment and have a wide range of emotional expression or resolutions have beneficial effects on emotional wellbeing. We will use the information from this study to help us to evaluate the use of this intervention to minimize emotional distress among HCT caregivers.

The proposed research will use a double-blind randomized controlled design to pilot test a model for how stories shared by a panel of HCT survivors impact the psychosocial well-being of the digital stories (DS) intervention condition of 55 patients who recently underwent HCT and their respective caregivers compared with 55 people in an information control (IC) condition and their caregivers (total 220 participants; N=110 per condition). Participants, recruited from the Mayo Clinic Arizona Cancer Center, will be randomly assigned to one of two conditions: the DS intervention or the IC video condition. Participants will questionnaires at baseline (T1), after the 4-week intervention (T2), and 3 months (100 days) later (T3).

The objectives of this study are to determine feasibility of adherence to a dyad-based PA intervention (# of sessions attended and Halo wear adherence) for HCT recipients and caregivers (15 dyads) using a single-group pre-post design, to determine acceptability of the intervention (dimensions of treatment satisfaction), and to describe patterns of change in PA and communal coping from baseline to follow-up, and in tone across intervention sessions. 

The purpose of this study is to see the effect of a chemotherapy treatment for patients with myelodysplastic syndrome before donor stem cell transplant. Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells, and may prevent the myelodysplastic syndrome from coming back after the transplant.

The specific aims of this study are to determine feasibility of recruitment, adherence, and retention of a couple-based PA intervention in a pilot RCT, to determine acceptability of the intervention (multiple dimensions of treatment satisfaction); and to describe changes in PA, physical endurance, and global physical health from baseline to follow-up as a function of randomized condition. These activities will prepare us to test efficacy of the intervention in a fully powered RCT to improve well-being, test mechanisms of action, and identify potential moderators of treatment response.

Does Tai Chi Easy (TCEasy), a simple and repetitive form of exercise that consists of movements with meditation, improve quality of life in those afflicted with multiple myeloma undergoing autologous stem cell transplantation?

The purpose of this study is to understand the need and gap in interventions addressing financial burden from a patient perspective, and develop a psychoeducational intervention directed towards decreasing financial distress in patients undergoing cancer treatment based on the knowledge gained.

The purpose of this study is to determine the feasibility and benefit of a patient-reported outcomes quality of life tool for hematology and medical oncology.

This research trial studies medical chart review in determining outcomes of second-line therapy in patients with acute graft-versus-host disease previously treated with extracorporeal photopheresis or other systemic therapies. Gathering information about second-line therapy in patients with acute graft-versus-host disease may help doctors learn more about the disease and find better treatment.

This randomized study will compare a personalized Survivorship Care Plan (SCP) template with usual care (no SCP). The investigators hypothesize that the personalized SCP that incorporates patient specific treatment exposures and provides a framework for long term followup based on those exposures and subsequent risks for late complications will enhance patient survivorship confidence in knowledge, increase adherence to recommended healthcare, improve health behaviors and reduce HCT-related emotional distress.

The purpose of this study is to evaluate safety, tolerability, pharmacokinetics, and effectiveness of SER-155 in adults undergoing hematopoietic stem cell transplantation to reduce the risk of infection and graft vs. host disease.

This study is investigating the supportive care needs, and levels of social support and distress, in adult patients who are receiving or have recently completed treatment for cancer. Research has shown that when cancer patients are supported with resources to help them cope with the cancer and treatment experience, that they are better able to tolerate and cope with their treatment and its impact.