Alexander C. Egbe, M.B.B.S., M.P.H.

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta. 

The primary study objectives are to examine the therapeutic potential of Tadalafil in improving endothelial function, hemodynamic capabilities, and end-organ function in patients who have previously undergone a Fontan Palliation.

The purpose of this study is to create a standardized cardiac MRI imaging protocol for patients with Congenital Heart Disease. 

The purpose of this study is to provide all studies that contribute to the Mayo Clinic Adult Congenital Heart Disease (MACHD) Registry with a control cohort, this study will combine all testing needed for each of the studies. 

The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise,  to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise.

The purpose of this study is to assess invasive hemodynamic indices at rest and during supine cycling exercise in healthy patients. 

These will serve as healthy controls and will be used for comparisons in the analysis of data from the Mayo Clinic Adult Congenital Heart Disease Registry (MACHD Registry). 

The purpose of this study is to explain the functional change mechanism linking right atrial (RA) hypertension, right heart (RH) remodeling and onset of symptoms such as arrhythmias and impaired aerobic capacity, since symptomatic status is a risk factor for mortality in the Tetralogy of Fallot (TOF) population.

The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to  determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.

The purpose of this study is to compare changes in RV structure and function, biomarkers, and patient reported outcomes between TOF patients randomized to an ARNI vs placebo.

The purpose of this study is to determine if a biomarker assay obtained peripartum (1st-3rd trimester and post-partum) in patients with adult congenital heart disease can predict future risk of cardiovascular adverse events and determine if temporal changes in biomarkers levels throughout the peripartum period can provide a better risk prediction compared to samples taken at a single time-point.

The purpose of this study is to compare the difference in the ability to detect blood flow abnormalities between invasive assessments performed at rest versus exercise.

The purpose of this study is to explore the potential role of NOAC as an alternative therapy in the congenital heart disease population.

The primary purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between echocardiographic assessments performed at rest versus exercise. 

The purpose of this study is to determine the optimal medical therapy to improve left ventricular (LV) function. Improvement in LV function has the potential to reduce the burden of heart failure and improve clinical outcomes in the Tetralogy of Fallot (TOF) population.

The purpose of this study is to determine if the medication, sildenafil (also known as Revatio), can slow or stop the progression of liver disease in patients who previously had a Fontan operation.

The purpose of this study is to:

1. Define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing.
2. Determine the role of rest-exercise echocardiography for the assessment hemodynamics in Fontan physiology.
3. Evaluate the clinical impact of pulmonary vascular disease and ventricular diastolic dysfunction.

This study is designed to determine if exercise echocardiography will identify ventricular and vascular function abnormalities in patients with COA that are not apparent at rest, and that exercise-induced ventricular and vascular dysfunction will predict clinical outcomes.