Alexander C. Egbe, M.B.B.S., M.P.H.

The primary study objectives are to examine the therapeutic potential of Tadalafil in improving endothelial function, hemodynamic capabilities, and end-organ function in patients who have previously undergone a Fontan Palliation.

The purpose of this study is to create a standardized cardiac MRI imaging protocol for patients with Congenital Heart Disease. 

The purpose of this study is to provide all studies that contribute to the Mayo Clinic Adult Congenital Heart Disease (MACHD) Registry with a control cohort, this study will combine all testing needed for each of the studies. 

The purpose of this study is to explain the functional change mechanism linking right atrial (RA) hypertension, right heart (RH) remodeling and onset of symptoms such as arrhythmias and impaired aerobic capacity, since symptomatic status is a risk factor for mortality in the Tetralogy of Fallot (TOF) population.

The primary purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between echocardiographic assessments performed at rest versus exercise. 

The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to  determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.

This study is designed to determine if exercise echocardiography will identify ventricular and vascular function abnormalities in patients with COA that are not apparent at rest, and that exercise-induced ventricular and vascular dysfunction will predict clinical outcomes. 

The purpose of this study is to explore the potential role of NOAC as an alternative therapy in the congenital heart disease population.

The purpose of this study is to determine the optimal medical therapy to improve left ventricular (LV) function. Improvement in LV function has the potential to reduce the burden of heart failure and improve clinical outcomes in the Tetralogy of Fallot (TOF) population.

The purpose of this study is to determine if the medication, sildenafil (also known as Revatio), can slow or stop the progression of liver disease in patients who previously had a Fontan operation.

The purpose of this study is to:

1. Define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing.
2. Determine the role of rest-exercise echocardiography for the assessment hemodynamics in Fontan physiology.
3. Evaluate the clinical impact of pulmonary vascular disease and ventricular diastolic dysfunction.