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Clinical Studies


  • A Pilot Trial to Evaluate the Feasibility of Intraoperative Microdialysis during Neurosurgery for Central Nervous System Malignancies Rochester, Minn.

    The purpose of this study is to evaluate the safety and feasibility of intraoperative microdialysis during surgical procedures for central nervous system malignancies.

  • Cerebrospinal Fluid Biomarkers for Brain Tumors Rochester, Minn.

    The purpose of this study is to help generate a repository of Cerebrospinal  Fluid (CSF) samples relevant to neuro-oncology research that may facilitate the identification of biomarkers that are predictive of disease burden, therapeutic susceptibility or response to therapy. This protocol will also provide a vehicle for CSF access for patients or providers wishing to generate or evaluate individualized biomarkers as part of other research or individualized therapy protocols.

  • Multimodality Functional Brain Mapping Rochester, Minn.

    The purpose of this study is to establish a prospective repository of detailed patient-specific information regarding the structure and function of human brain tissue impacted by disease and therapeutic interventions, detailing the neurologic and cognitive performance during the course of disease management.



  • Ommaya Reservoir Placement for Prospective Biomarker Collection Rochester, Minn.

    The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated tumor surgery in order to facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of exploratory and future tumor biomarkers for individualized monitoring.



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  • Surgical Resection of Latent Brain Tumors Prior to Recurrence Rochester, Minn.

    The purpose of this study is to evaluate the safety and feasibility of surgical resection for pre-recurrent brain tumors. Eligible patients with surgically accessible latent tumors desiring surgical resection will be enrolled to prospectively track short- and long-term outcomes. Safety will be evaluated by quantifying rates of surgical morbidity as compared to patients undergoing RT after surgery, or no surgery for similar latent disease. Variables evaluated will include postoperative complications including death within 30 days, wound infection, length of hospital stay, and readmission rates.