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This is a pilot study to evaluate whether targeting inflammation will help reduce markers of insulin resistance inflammation, bone resorption and physical dysfunction in elderly women with gait disturbance. Positive results of this study would lead to the development of a larger clinical trial examining the effects of this intervention on age-related dysfunction.
The purpose of this study is test the effectiveness of the senolytic drug (Fisetin) in reducing senescent cell abundance in blood in elderly adults.
The primary purpose of this research study is to collect a large enough sample of fat cells (preadipocytes) and blood from patients undergoing surgery to establish a bank of samples for use by researchers to begin to understand what factors regulate the ability of fat tissue to grow better in some people than others.
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