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Clinical Studies

Closed for Enrollment

  • Design and Pilot Implementation of a Web Based Real Time Clinical Decision Support Tool. (Checklist for Early Recognition and Treatment of Acute Illness in Pediatrics. CERTAINp Rochester, Minn.

    In the developed world critical illness is routinely treated in an intensive care unit (ICU) by highly specialized physicians, nurses and support staff. This model of intensive care is spreading rapidly to low and middle income countries and as it spreads, challenges and limitations to this model arise. In resource-poor settings, inadequate human resources, training, and equipment all present barriers to safe and effective use of life-saving procedures. The advances in medical informatics and human factors engineering have provided tremendous opportunity for novel and user-friendly clinical decision support (CDS) tools that can be applied in a complex and busy hospital setting. Real-time data feeds and standardized patient care tasks in a simulated acute care environment have been proven to have a significant advantage of a novel interface (compared to a conventional) in reducing provider cognitive load and errors. Currently researchers within the investigator's research group have developed and are pilot testing a simple electronic decision support tool: CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness). This tool has been successfully tested and validated in simulated settings and is being implemented as pilot study in 18 countries. Worldwide infant and early childhood mortality continues to be very high partly due to the inability to recognize and respond aggressively to critical illnesses. Investigators expect that adaptation of the algorithms from CERTAIN has potential to be a powerful tool to improve on the medical care of children in developing countries. Investigators aim in this project is 1) to develop a pediatric adaptation of CERTAIN (CERTAINp) and 2) to implement it into clinical practice in resource-poor settings and evaluate the impact of the tool on the processes and patient outcomes.

  • Pediatric Intensive Care Unit (PICU) Liberation ABCDEF Bundle Quality Improvement Collaborative to Accomplish Early Wake Up and Mobilization: Implementation, Evaluation, and Process (Wake ME Up): A Comprehensive, Holistic Approach to Sedation, Pain, Delirium, Early Mobilization, and Family Engagement in the Pediatric Intensive Care Unit Rochester, Minn.

    The purpose of this study is to evaluate the subjective impressions on workload demands compared to perceived benefits of a new quality improvement plan of patient care in the Pediatric Intensive Care Unit. The frequency and length of education and training sessions will also be recorded, and PICU patient charts (electronic health records) will be reviewed to document the number and frequency of consults and adherence to the patient care plan.

  • Ventilator-Associated Infections Point Prevalence Study (VAIN Study) (VAIN) Rochester, Minn.

    The purpose of this research is to study the natural history of "ventilator associated pneumonia" and its causes and treatments.